Description

Bisoprolol-D5 is a high-purity, stable isotope-labeled analog of the widely prescribed β-blocker Bisoprolol, specifically deuterated at five positions. This compound is an essential internal standard for the precise and accurate quantification of Bisoprolol in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for researchers and quality control laboratories in the pharmaceutical and contract research organization (CRO) sectors, enabling reliable pharmacokinetic studies, bioequivalence testing, and method development.

Application

• Internal Standard for Bioanalysis: Primary use as a deuterated internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) for the quantification of Bisoprolol in plasma, serum, and other biological fluids.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and preclinical research.
• Bioequivalence Testing: Critical for ensuring analytical method accuracy when comparing generic and branded formulations of Bisoprolol.
• Method Development & Validation: Serves as a key reference material for developing, optimizing, and validating robust analytical methods in regulatory environments.
• Pharmaceutical Quality Control: Used in impurity profiling and stability-indicating assay methods for Bisoprolol active pharmaceutical ingredient (API) and finished dosage forms.
• Forensic & Clinical Toxicology: Aids in the specific and sensitive detection of Bisoprolol in cases of overdose or therapeutic drug monitoring.

Basic Information

Product Name	Bisoprolol-D5
CAS No.	1189881-87-5
Molecular Formula	C18H26D5NO4
Molecular Weight	328.46 g/mol (approx.)
Synonyms	1-(4-{[2-(1-Methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]-2-propanol-d5; Bisoprolol (phenyl-d5); Bisoprolol-d5; Bisoprolol (phenyl ring-d5); 1-[4-[[2-(Propan-2-yloxy)ethoxy]methyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol-d5; (±)-1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)-2-propanol-d5; Isotopically Labeled Bisoprolol
EINECS	Contact for details

Quality Control

Our Bisoprolol-D5 is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and confirming the absence of interfering impurities. We adhere to relevant industry guidelines for reference standards to support GMP and GLP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.