Description

2-(3-Chlorophenyl)-1-(3-Pyridinyl-D4)-1-Ethanone CAS NO 1189880-12-3 is a high-purity, deuterium-labeled chemical reference standard, essential for advanced analytical and research applications. Its core value lies in providing a stable, isotopically-labeled internal standard for precise quantification and metabolic pathway tracing in complex matrices. This compound is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and forensic analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard in liquid chromatography-tandem mass spectrometry for the accurate quantification of its non-deuterated analog or related metabolites in biological samples.
• Drug Metabolism Studies (DMPK): Used in pharmacokinetic and metabolic stability assays to track absorption, distribution, metabolism, and excretion (ADME) pathways, leveraging the deuterium label for differentiation.
• Bioanalytical Method Development: Employed to validate and optimize analytical methods, ensuring specificity, accuracy, and precision in detecting target analytes in plasma, serum, or urine.
• Forensic and Clinical Toxicology: Acts as a reference material for the identification and confirmation of specific substances or their breakdown products in forensic investigations or clinical screenings.
• Isotope Dilution Mass Spectrometry (IDMS): A key component in IDMS, a definitive method used for achieving high-accuracy measurements in certified reference material production and regulatory analysis.
• Chemical Research & Synthesis: Utilized as a building block or tracer in synthetic chemistry research to study reaction mechanisms or to synthesize novel deuterated compounds for various applications.

Basic Information

Product Name	2-(3-Chlorophenyl)-1-(3-Pyridinyl-D4)-1-Ethanone
CAS No.	1189880-12-3
Molecular Formula	C13H7D4ClNO
Molecular Weight	232.71 g/mol
Synonyms	1-(3-Chlorophenyl)-2-(pyridin-3-yl-D4)ethanone; 3-Chlorophenyl 3-Pyridinyl-D4 Ketone; 2-(3-Chlorophenyl)-1-(pyridin-3-yl-D4)ethanone; 1-(3-Chlorophenyl)-2-(3-pyridinyl-D4)ethanone; Deuterated 3'-Chloro-3-Pyridinyl Phenyl Ketone; [D4]-2-(3-Chlorophenyl)-1-(3-pyridinyl)ethanone; 3-Pyridinyl-D4, 2-(3-chlorophenyl)ethanone derivative
EINECS	Contact for details

Quality Control

Every batch of our deuterated standards is produced and analyzed under strict quality control protocols to ensure isotopic purity, chemical purity, and stability. We provide comprehensive Certificates of Analysis (COA) detailing results from NMR (for deuterium incorporation), HPLC/LC-MS (for chemical and isotopic purity), and other relevant spectroscopic analyses. Our quality system is designed to meet the exacting requirements of GMP/GLP-compliant laboratories and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C to ensure optimal stability of the deuterium label and compound integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (LC-MS)	≥98.0 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.