Description

3-(4-Chlorophenyl-D4)Glutaric Acid is a deuterium-labeled analog of a key glutaric acid derivative, serving as a critical stable isotope-labeled internal standard. This high-purity compound is essential for ensuring accuracy and reliability in quantitative analytical methods, particularly mass spectrometry. It is primarily required by researchers and quality control laboratories in the pharmaceutical, agrochemical, and advanced material science sectors for method development, validation, and regulatory compliance.

Application

• Pharmaceutical Research & Development: As a stable isotope-labeled internal standard (SIL-IS) for the precise quantification of its non-deuterated counterpart or related metabolites in bioanalytical studies using LC-MS/MS.
• Metabolomics and Pharmacokinetics (PK/ADME): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion by minimizing matrix effects and ion suppression in complex biological samples.
• Impurity Profiling and Degradation Studies: Used as a reference standard to identify and quantify process-related impurities or degradation products in active pharmaceutical ingredients (APIs).
• Agrochemical Analysis: Supports the development of robust analytical methods for the detection and quantification of pesticides or their environmental breakdown products.
• Chemical Synthesis Intermediate: The deuterated phenyl ring makes it a valuable building block for synthesizing more complex deuterium-labeled compounds for mechanistic studies or as advanced materials.
• Quality Control & Assurance: Serves as a certified reference material (CRM) to calibrate instruments and validate analytical methods in compliance with GLP and GMP guidelines.

Basic Information

Product Name	3-(4-Chlorophenyl-D4)Glutaric Acid
CAS No.	1189874-68-7
Molecular Formula	C11H6D4ClO4
Molecular Weight	243.68 g/mol (for deuterated form)
Synonyms	3-(4-Chlorophenyl-d4)pentanedioic acid; Glutaric acid, 3-(4-chlorophenyl-d4)-; 3-(p-Chlorophenyl-d4)glutaric acid; Deuterated 3-(4-Chlorophenyl)glutaric Acid; [2H4]-3-(4-Chlorophenyl)glutaric Acid; 3-(4-Chloro-d4-phenyl)glutaric acid; Stable Isotope Labeled 3-(4-Chlorophenyl)glutaric Acid
EINECS	Contact for details

Quality Control

Every batch of 3-(4-Chlorophenyl-D4)Glutaric Acid is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic enrichment (D-atom %), and impurity profile is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0% (by MS)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.