Description

1,3-Dihydro-1-D5-Phenyl-2H-Indol-2-One is a high-purity, deuterium-labeled isotopologue of oxindole, a key structural motif in medicinal chemistry. This compound is specifically designed for use as an internal standard in quantitative mass spectrometry, providing superior accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential analytical tool for pharmaceutical R&D, contract research organizations (CROs), and academic laboratories focused on drug discovery and development.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically labeled internal standard for the precise quantification of oxindole-based compounds and their metabolites in biological matrices.
• Pharmaceutical Research: Critical for drug metabolism and pharmacokinetics (DMPK) studies, enabling accurate measurement of absorption, distribution, metabolism, and excretion (ADME) profiles.
• Bioanalytical Method Development: Used to validate and calibrate sensitive analytical methods, ensuring compliance with regulatory guidelines (e.g., FDA, EMA) for bioanalysis.
• Metabolite Identification: Aids in the structural elucidation and tracking of metabolites in complex biological systems.
• Chemical Reference Standard: Serves as a certified reference material (CRM) for quality control and assurance in analytical laboratories.
• Isotope Dilution Analysis: Employed in advanced analytical techniques to correct for matrix effects and instrument variability, enhancing data integrity.

Basic Information

Product Name	1,3-Dihydro-1-D5-Phenyl-2H-Indol-2-One
CAS No.	1189871-32-6
Molecular Formula	C14H6D5NO
Molecular Weight	214.27 g/mol
Synonyms	1,3-Dihydro-1-D5-phenyl-2H-indol-2-one; 1,3-Dihydro-1-(pentadeuteriophenyl)-2H-indol-2-one; Oxindole-1-D5-phenyl; 2-Indolinone-1-D5-phenyl; [1,2,3,4,5-D5]-1-Phenyl-1,3-dihydro-2H-indol-2-one; Deuterated Oxindole Derivative; (1-D5-Phenyl)oxindole; CAS 1189871-32-6
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity for demanding analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (≥95%), and analytical data is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (MS)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.