Description

Ethyl 2-Amino-2-Methyl-1-Propionate-D6 Hydrochloride is a high-purity, deuterium-labeled derivative of the amino acid ester, specifically designed for advanced analytical and research applications. This compound serves as a critical internal standard in quantitative mass spectrometry, enabling precise and reliable measurements in complex biological matrices. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and agrochemical sectors who require uncompromised accuracy in metabolic studies, pharmacokinetics, and method development.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable isotope-labeled internal standard for the accurate quantification of its non-deuterated counterpart in bioanalytical assays.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies, including absorption, distribution, metabolism, and excretion (ADME) profiling.
• Biomarker Research: Enables precise measurement of related amino acid metabolites in clinical and preclinical studies for disease biomarker discovery.
• Agrochemical Analysis: Applied in the residue analysis and environmental fate studies of related agrochemical compounds.
• Method Development & Validation: Critical for developing and validating robust, regulatory-compliant analytical methods in GLP/GMP environments.
• Synthetic Intermediate: Can serve as a specialized building block in the synthesis of deuterium-labeled peptides or more complex molecular probes.

Basic Information

Product Name	Ethyl 2-Amino-2-Methyl-1-Propionate-D6 Hydrochloride
CAS No.	1189862-01-8
Molecular Formula	C7H10D6ClNO2
Molecular Weight	187.71 g/mol
Synonyms	Ethyl 2-Amino-2-Methylpropionate-D6 Hydrochloride; Ethyl 2-Aminoisobutyrate-D6 Hydrochloride; 2-Amino-2-methylpropionic acid ethyl ester-D6 hydrochloride; AIB ethyl ester-D6 hydrochloride; Ethyl 2-aminoisobutyrate-d6 HCl; Ethyl 2-methylalanine-D6 ester hydrochloride; (2-Amino-2-methyl-propionic acid ethyl ester)-d6 hydrochloride
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-2-Methyl-1-Propionate-D6 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay, isotopic enrichment, and impurity profiles via NMR, HPLC, and mass spectrometry. We adhere to relevant industry guidelines to support your GLP and GMP compliance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.