Description

4-Chloro-n-(Methyl-D3)Pyridine-2-Carboxamide is a high-purity, deuterium-labeled chemical building block of significant importance in advanced research and development. This compound is specifically designed for use as a stable isotope-labeled internal standard in quantitative analytical methods, such as LC-MS/MS, ensuring unparalleled accuracy and reliability in trace-level detection. It is primarily utilized by pharmaceutical, agrochemical, and analytical chemistry laboratories engaged in method development, pharmacokinetic studies, and metabolic research.

Application

• Internal Standard for Mass Spectrometry: Serves as a critical deuterated internal standard (IS) for the precise quantification of its non-deuterated counterpart or related analogs in complex biological matrices using LC-MS/MS.
• Pharmaceutical Metabolite Studies: Enables accurate tracking and measurement of drug metabolites in pharmacokinetic (PK) and pharmacodynamic (PD) research.
• Biomarker Analysis: Used in the development and validation of sensitive assays for biomarker discovery and validation in clinical and preclinical samples.
• Agrochemical Research: Facilitates residue analysis and environmental fate studies of pyridine-based agrochemicals.
• Chemical Synthesis Intermediate: Acts as a specialized, labeled intermediate for the synthesis of more complex deuterated molecules for research purposes.
• Regulatory Compliance Testing: Supports method development for GLP (Good Laboratory Practice) and GMP (Good Manufacturing Practice) compliant analytical procedures requiring isotope dilution techniques.

Basic Information

Product Name	4-Chloro-n-(Methyl-D3)Pyridine-2-Carboxamide
CAS No.	1189858-48-7
Molecular Formula	C7H4D3ClN2O
Molecular Weight	171.60 g/mol (for monoisotopic mass)
Synonyms	4-Chloro-N-(trideuteriomethyl)pyridine-2-carboxamide; 2-Pyridinecarboxamide, 4-chloro-N-(methyl-d3)-; N-(Methyl-d3)-4-chloropyridine-2-carboxamide; 4-Chloro-N-(methyl-d3)picolinamide; Deuterated 4-Chloro-N-methylpicolinamide; d3-4-Chloro-N-methyl-2-pyridinecarboxamide; (Methyl-d3)-4-chloro-2-picolinamide; 4-Chloro-2-picolinamide-N-methyl-d3
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-n-(Methyl-D3)Pyridine-2-Carboxamide is manufactured and analyzed under strict quality protocols to ensure the high chemical purity and isotopic enrichment required for analytical standards. Our products undergo rigorous quality testing, including NMR, HPLC, and MS, to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (d3)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.