Description

1-[(tert-Butyldimethylsilyl)Oxy]-2-Methyl-2-Propanol-D6 is a deuterated derivative of a tert-butyldimethylsilyl (TBDMS) protected alcohol, specifically designed for use as a stable isotope-labeled intermediate. This compound is essential for research and development in analytical chemistry, providing a non-radioactive isotopic tracer for precise metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical researchers, contract research organizations (CROs), and advanced material scientists requiring high-purity labeled building blocks.

Application

• Deuterated Internal Standards for quantitative mass spectrometry (LC-MS, GC-MS) in bioanalysis and environmental testing.
• Synthetic Intermediate in the preparation of deuterium-labeled active pharmaceutical ingredients (APIs) for drug metabolism and pharmacokinetics (DMPK) studies.
• NMR Spectroscopy as a probe or standard due to its distinct deuterium signature, aiding in structural elucidation and reaction monitoring.
• Isotope Labeling Research in academic and industrial settings for tracing reaction pathways and studying mechanistic details.
• Precursor for Specialty Materials, potentially used in the synthesis of labeled polymers or organic electronic materials where isotopic purity affects properties.

Basic Information

Product Name	1-[(tert-Butyldimethylsilyl)Oxy]-2-Methyl-2-Propanol-D6
CAS No.	1189732-27-1
Molecular Formula	C10H18D6O2Si
Molecular Weight	206.40 g/mol
Synonyms	2-Methyl-2-[(tert-butyldimethylsilyl)oxy]propan-1-ol-d6; 2-Methyl-2-[(TBDMS)oxy]-1-propanol-d6; 1-(tert-Butyldimethylsiloxy)-2-methyl-2-propanol-d6; Deuterated TBDMS-protected neopentyl glycol; (2-Methyl-2-[(tert-butyldimethylsilyl)oxy]propyl-1,1,1,3,3,3-d6) alcohol; tert-Butyldimethylsilyl ether of deuterated 2-methyl-2-propan-1-ol; TBDMS-D6 alcohol derivative; Isotopically labeled silyl ether.
EINECS	Contact for details

Quality Control

Our deuterated chemicals are produced and tested under strict quality management to ensure high isotopic and chemical purity, critical for sensitive analytical applications. Each batch is characterized by advanced techniques including NMR, HPLC, and GC-MS to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption, which can compromise stability and purity. Handle and store under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to ensure optimal shelf life.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.