Description

N2-Acetyl-9-(2-Acetoxyethoxymethyl-D4)Guanine is a deuterated derivative of acyclovir, a key nucleoside analogue, designed for advanced pharmaceutical research and development. This compound is crucial for metabolic and pharmacokinetic studies, providing enhanced stability and traceability in analytical applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel antiviral agents and as an internal standard in mass spectrometry.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for quality control and analytical method validation in drug manufacturing.
• Metabolic Tracing: Used in deuterium-labeled studies to investigate drug metabolism, absorption, and excretion pathways.
• Internal Standard for LC-MS/MS: Essential for the accurate quantification of acyclovir and related compounds in bioanalytical assays due to its isotopic label.
• Antiviral Drug Research: A key intermediate or probe in the research and development of next-generation nucleoside antiviral therapeutics.
• Chemical Synthesis: Employed as a specialized building block for the synthesis of more complex labeled pharmaceutical compounds.
• Regulatory Submissions: Supports drug approval dossiers by providing characterized materials for stability and impurity profiling studies.

Basic Information

Product Name	N2-Acetyl-9-(2-Acetoxyethoxymethyl-D4)Guanine
CAS No.	1189728-07-1
Molecular Formula	C12H14D4N5O5
Molecular Weight	312.31 g/mol
Synonyms	9-[(2-Acetoxyethoxy)methyl-D4]-N2-acetylguanine; Deuterated Acyclovir N2-Acetate; 2-Amino-9-[(2-acetoxyethoxy)methyl-D4]-1,9-dihydro-6H-purin-6-one N2-Acetate; Acyclovir-d4 N2-Acetate; [2-(Acetyloxy)ethoxy-D4]methyl N2-acetyl-2-amino-1,9-dihydro-6H-purin-6-one; ACV-d4 N-Acetyl Derivative; Deuterium Labeled Acyclovir Impurity/Intermediate
EINECS	Contact for details

Quality Control

Every batch of N2-Acetyl-9-(2-Acetoxyethoxymethyl-D4)Guanine is manufactured under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments, including HPLC purity, isotopic enrichment (D%), and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is supplied with each shipment, ensuring traceability and compliance with research and pharmaceutical standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.