Description

4-(Methyl-D3-Amino)-1-(3-Pyridyl)-1-Butanone Dihydrochloride is a high-purity, deuterated chemical reference standard of significant value in advanced analytical and research fields. This compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry and metabolic studies, where precise isotopic labeling is required. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and pharmacokinetics (DMPK) research, bioanalytical method development, and forensic analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a stable isotope-labeled internal standard for the precise quantification of its non-deuterated analog or related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical compounds.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate highly sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Forensic and Clinical Toxicology: Employed as a reference material for the accurate detection and quantification of specific substances or their biomarkers in forensic and clinical settings.
• Isotope Dilution Mass Spectrometry (IDMS): A key component in IDMS, a gold-standard technique for achieving high accuracy and minimizing matrix effects in quantitative analysis.
• Metabolomics Research: Facilitates the tracking and identification of metabolic pathways and flux analysis in biochemical research.

Basic Information

Product Name	4-(Methyl-D3-Amino)-1-(3-Pyridyl)-1-Butanone Dihydrochloride
CAS No.	1189727-40-9
Molecular Formula	C11H17D3Cl2N2O
Molecular Weight	270.22 g/mol
Synonyms	4-[(Methyl-d3)amino]-1-(3-pyridinyl)-1-butanone dihydrochloride; Deuteronated Cotinine-d3 Dihydrochloride; (S)-(-)-Cotinine-d3 Dihydrochloride; 1-Methyl-5-(3-pyridyl)-2-pyrrolidinone-d3 Dihydrochloride; Cotinine N-Methyl-d3 Dihydrochloride; Cotinine-d3 (N-Methyl) Dihydrochloride; 5-(3-Pyridyl)-1-methyl-2-pyrrolidinone-d3 Dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of 4-(Methyl-D3-Amino)-1-(3-Pyridyl)-1-Butanone Dihydrochloride is manufactured and tested under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, with comprehensive characterization using advanced techniques including NMR, HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing batch-specific purity, isotopic purity (D-enrichment), and analytical data are provided to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.