Description

Bupropion-D9 Hydrochloride is a deuterated, isotopically labeled analog of the active pharmaceutical ingredient bupropion, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and reliability in pharmacokinetic and bioanalytical studies, where precise measurement is critical. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in drug metabolism and mass spectrometry.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the accurate quantification of bupropion and its metabolites in biological matrices (plasma, serum, urine) during bioanalytical method development and validation.
• Pharmacokinetic and Drug Metabolism Studies (DMPK): Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used as a certified reference material for confirming the presence and concentration of bupropion in forensic analyses and therapeutic drug monitoring.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for bupropion hydrochloride drug substances and finished dosage forms.
• Stable Isotope Labeled Research: Serves as a tool in mechanistic studies to elucidate metabolic pathways and degradation products.

Basic Information

Product Name	Bupropion-D9 Hydrochloride
CAS No.	1189725-26-5
Molecular Formula	C13H9D9ClNO • HCl
Molecular Weight	310.27 g/mol (approx.)
Synonyms	(±)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone-D9 Hydrochloride; 2-(tert-Butylamino)-1-(3-chlorophenyl)propan-1-one-D9 Hydrochloride; Bupropion-d9 HCl; Amfebutamone-D9 Hydrochloride; Zyban-d9 (labeled analog); Wellbutrin-d9 (labeled analog)
EINECS	Contact for details

Quality Control

Our Bupropion-D9 Hydrochloride is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm deuterium incorporation and chemical purity. A comprehensive Certificate of Analysis (COA) is provided, detailing assay, isotopic enrichment, and impurity profiles, supporting compliance with GMP and ISO 17025 principles for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥98.0% (anhydrous basis)
Isotopic Purity (Deuterium Enrichment)	≥98.0 atom % D
Chemical Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.