Description

1-(2,3,4,5,6-Pentadeuteriophenyl)-n-Prop-2-Ynylpropan-2-Amine is a deuterated organic compound, specifically a deuterium-labeled analog of a propargylamine derivative. This compound is of significant value as a stable isotope-labeled internal standard or tracer in analytical chemistry and life science research, enabling precise quantification and metabolic pathway studies. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in advanced mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS/MS and GC-MS methods for drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolic Pathway Tracing: Serves as a deuterium-labeled tracer to investigate the biotransformation and distribution of its parent compound in biological systems.
• Pharmaceutical Impurity Profiling: Employed in the development and validation of analytical methods to identify and quantify related substances and degradation products.
• Neurochemical Research: As a deuterated analog of a propargylamine, it finds application in neuroscience research related to monoamine oxidase (MAO) activity and neurotransmitter regulation.
• Chemical Synthesis Intermediate: Acts as a specialized building block for the synthesis of more complex deuterium-labeled molecules for research purposes.
• Quality Control & Method Development: Critical for ensuring accuracy and reproducibility in high-end analytical laboratories requiring isotope-dilution techniques.

Basic Information

Item	Detail
Product Name	1-(2,3,4,5,6-Pentadeuteriophenyl)-n-Prop-2-Ynylpropan-2-Amine
CAS No.	1189725-08-3
Molecular Formula	C12D5H10N
Molecular Weight	178.26 g/mol (for C12H15N, deuterated form approx. 183.29)
Synonyms	1-(Pentadeuteriophenyl)-2-propyn-1-ylpropan-2-amine; N-(2-Propynyl)-α-methyl-pentadeuteriobenzeneethanamine; Deuterated N-Propargylamphetamine-d5; 1-(2,3,4,5,6-Pentadeuterophenyl)-2-propyn-1-ylpropan-2-amine; N-Methyl-N-(2-propynyl)benzene-d5-ethanamine; (RS)-N-(2-Propynyl)-α-methyl-(phenyl-d5)ethylamine; 1-Phenyl-2-(prop-2-yn-1-ylamino)propane-d5
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced and tested under strict quality management to ensure isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and Mass Spectrometry to confirm deuterium incorporation and chemical purity. Certificates of Analysis (COA) are provided, detailing isotopic enrichment (typically >98 atom % D), chemical purity, and analytical results. We adhere to relevant ISO 9001 guidelines for research chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Keep the container sealed under an inert atmosphere such as nitrogen to ensure long-term stability of the deuterated compound.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (by GC/HPLC)	≥ 97%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.