Description

3,4,5-Trimethoxybenzaldehyde-D9 is a high-purity, deuterium-labeled derivative of 3,4,5-trimethoxybenzaldehyde, a key synthetic intermediate. This stable isotope-labeled compound is essential for creating internal standards in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and forensic analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard for the precise quantification of 3,4,5-trimethoxybenzaldehyde and related metabolites or analogs in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in pharmacokinetic and bioavailability studies to track and quantify parent drugs and their metabolites, improving data accuracy and regulatory submission quality.
• Pharmaceutical Impurity Profiling: Enables accurate measurement of trace impurities and degradants in active pharmaceutical ingredients (APIs) and finished drug products during stability testing and quality control.
• Forensic and Toxicological Analysis: Provides a reliable reference standard for the detection and quantification of specific compounds in forensic investigations and clinical toxicology.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in this gold-standard analytical technique for achieving the highest possible accuracy in quantitative analysis.
• Biochemical Research: Utilized in mechanistic studies to trace biochemical pathways and reaction mechanisms involving the trimethoxybenzaldehyde moiety.

Basic Information

Item	Detail
Product Name	3,4,5-Trimethoxybenzaldehyde-D9
CAS No.	1189721-06-9
Molecular Formula	C10D9H2O4
Molecular Weight	199.24 g/mol
Synonyms	Deuterated 3,4,5-Trimethoxybenzaldehyde; 3,4,5-Trimethoxybenzaldehyde-d9; Benzaldehyde-D9, 3,4,5-trimethoxy-; (2,3,4,5,6-Pentadeuterio-3,4,5-trimethoxyphenyl)formaldehyde; Gallaldehyde-D9, 3,4,5-trimethoxy-; TMBA-D9; Trimethoxybenzaldehyde Deuterated Standard
EINECS	Contact for details

Quality Control

Every batch of 3,4,5-Trimethoxybenzaldehyde-D9 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR (1H, 13C) and mass spectrometry to confirm deuteration level and identity. A detailed Certificate of Analysis (COA) providing batch-specific data on purity, isotopic enrichment, and solvent content is supplied with each shipment to ensure full traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere such as nitrogen or argon for long-term storage to maintain stability and isotopic integrity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuteration Degree)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.