Description

4-Methyl-11-(1,2,2,3,3-Pentadeuteriocyclopropyl)-5H-Dipyrido[2,3-E:2',3'-F][1,4]Diazepin-6-One is a deuterated derivative of a complex heterocyclic compound, offering a stable isotopic label for advanced research and development. This compound is crucial for applications requiring precise molecular tracking and metabolic pathway elucidation, where standard hydrogen isotopes are insufficient. It is primarily needed by pharmaceutical R&D teams, analytical laboratories, and academic institutions engaged in drug metabolism and pharmacokinetics (DMPK) studies, proteomics, and the development of novel therapeutic agents.

Application

• Internal Standard for Mass Spectrometry: Used as a high-purity, isotopically labeled internal standard in LC-MS/MS and GC-MS for the accurate quantification of its non-deuterated counterpart in complex biological matrices.
• Drug Metabolism Studies (DMPK): Essential for tracing the absorption, distribution, metabolism, and excretion (ADME) pathways of lead pharmaceutical compounds in preclinical research.
• Proteomics and Biomarker Research: Serves as a critical tool in quantitative proteomics for the development of stable isotope dilution assays to discover and validate disease biomarkers.
• Pharmacokinetic Modeling: Enables precise modeling of drug concentration over time in biological systems, improving the accuracy of pharmacokinetic parameters.
• Mechanistic Organic Chemistry Research: Acts as a deuterium-labeled probe in reaction mechanism studies to investigate kinetic isotope effects and reaction pathways.
• Reference Material for Analytical Method Development: Provides a certified reference material for the validation and calibration of sensitive analytical methods in regulatory environments.

Basic Information

Product Name	4-Methyl-11-(1,2,2,3,3-Pentadeuteriocyclopropyl)-5H-Dipyrido[2,3-E:2',3'-F][1,4]Diazepin-6-One
CAS No.	1189717-29-0
Molecular Formula	C17H12D5N3O
Molecular Weight	Contact for details
Synonyms	4-Methyl-11-(1,2,2,3,3-pentadeuteriocyclopropyl)-5H-dipyrido[2,3-e:2',3'-f][1,4]diazepin-6-one; Deuterated Dipyridodiazepinone Derivative; [2H5]-4-Methyl-11-cyclopropyl-5H-dipyrido[2,3-e:2',3'-f][1,4]diazepin-6-one; CAS 1189717-29-0; 4-Methyl-11-(cyclopropyl-d5)-5H-dipyrido[2,3-e:2',3'-f][1,4]diazepin-6-one; Stable Isotope Labeled Heterocycle
EINECS	Contact for details

Quality Control

Every batch of our 4-Methyl-11-(1,2,2,3,3-Pentadeuteriocyclopropyl)-5H-Dipyrido[2,3-E:2',3'-F][1,4]Diazepin-6-One is manufactured and analyzed under strict quality management systems. We guarantee high isotopic purity and chemical purity to meet the exacting standards of analytical and research applications. Comprehensive testing includes assay by HPLC, determination of isotopic enrichment by NMR and/or MS, and control of related substances. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.