Description

Memantine-D6 Hydrochloride is a deuterated isotopologue of the NMDA receptor antagonist memantine, where six hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and reproducibility in analytical methods. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in the quantitative bioanalysis of memantine in biological matrices such as plasma, serum, and urine.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Impurity Profiling and Degradation Studies: Used as a tracer in stability-indicating methods to identify and quantify potential degradants.
• Forensic and Doping Control Analysis: Provides a reliable standard for the confirmatory testing of memantine in forensic toxicology and anti-doping programs.
• Method Development and Validation: Fundamental for developing, optimizing, and validating robust analytical assays in compliance with GLP and GCP guidelines.
• Neuroscience Research: Supports isotopic labeling experiments to investigate the mechanistic pathways of NMDA receptor modulation.

Basic Information

Product Name	Memantine-D6 Hydrochloride
CAS No.	1189713-18-5
Molecular Formula	C12H15D6ClN
Molecular Weight	215.80 g/mol
Synonyms	3,5-Dimethyladamantan-1-amine-D6 hydrochloride; 1-Amino-3,5-dimethyladamantane-D6 hydrochloride; Memantine (hexadeuterated) hydrochloride; Memantine-D6 HCl; 3,5-Dimethyl-1-adamantylamine-D6 hydrochloride; 1,3-Dimethyl-5-aminoadamantane-D6 hydrochloride; Akatinol-D6 hydrochloride; Namenda-D6 hydrochloride
EINECS	Contact for details

Quality Control

Our Memantine-D6 Hydrochloride is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay, isotopic enrichment, and impurity profile. We adhere to relevant industry standards to support research conducted under GLP (Good Laboratory Practice) and regulatory submission requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.