Description

3-(2-Chloroethyl-D4)-2-Methyl-6,7,8,9-Tetrahydro-4H-Pyrido[1,2-A]Pyrimidin-4-One is a high-purity, deuterium-labeled chemical intermediate of significant importance in advanced research and development. This compound is specifically designed for use in analytical chemistry and pharmaceutical studies, where isotopic labeling is critical for tracking and quantification. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and academic sectors for applications such as metabolism studies, internal standards for mass spectrometry, and the synthesis of novel labeled compounds.

Application

• Internal Standard for Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a stable, isotopically labeled reference compound for the precise quantification of its non-deuterated counterpart or related metabolites in complex biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical candidates.
• Synthesis of Deuterated Active Pharmaceutical Ingredients (APIs): Acts as a key building block in the preparation of deuterium-enriched drug molecules, which can offer improved metabolic stability and pharmacokinetic properties.
• Biochemical Research: Employed in mechanistic studies to elucidate reaction pathways and enzyme mechanisms where hydrogen/deuterium exchange is relevant.
• Agrochemical Research: Utilized in the development and analysis of labeled pesticides or herbicides for environmental fate and residue studies.
• Analytical Method Development: Critical for validating and calibrating sensitive analytical methods in regulatory and quality control environments.

Basic Information

Product Name	3-(2-Chloroethyl-D4)-2-Methyl-6,7,8,9-Tetrahydro-4H-Pyrido[1,2-A]Pyrimidin-4-One
CAS No.	1189712-26-2
Molecular Formula	C11H11D4ClN2O
Molecular Weight	226.73 g/mol
Synonyms	2-Methyl-3-(2-chloroethyl-d4)-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; Deuterated Chloroethyl Pyridopyrimidinone; 3-(2-Chloroethyl-1,1,2,2-d4)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; 1189712-26-2; (2-Chloroethyl-d4)-Labeled Pyrimidinone Intermediate; Perdeuterated Chloroethyl Derivative; Tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one, 3-(2-chloroethyl-d4)-2-methyl-
EINECS	Contact for details

Quality Control

Every batch of 3-(2-Chloroethyl-D4)-2-Methyl-6,7,8,9-Tetrahydro-4H-Pyrido[1,2-A]Pyrimidin-4-One is manufactured and analyzed under strict quality management systems to ensure the highest standards of purity and isotopic enrichment required for research applications. Our quality assurance includes comprehensive analytical testing, with a Certificate of Analysis (COA) provided for each lot, detailing parameters such as chemical purity, isotopic purity (D-enrichment), and identity confirmation. We support compliance with relevant research and development guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.