Description

Diethyl-(6-Chloro1,2,3,4-Tetrahydro-2-Carbazolyl)Methyl-D3 Malonate is a high-purity, deuterium-labeled chemical intermediate of significant importance in advanced pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled building block, enabling precise metabolic and pharmacokinetic studies for new drug candidates. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing central nervous system (CNS) active agents and other specialized therapeutics where detailed mechanistic understanding is critical.

Application

• Pharmaceutical Intermediate: A key deuterated synthon in the multi-step synthesis of novel carbazole-based drug molecules.
• Metabolic Tracer: Used in Drug Metabolism and Pharmacokinetics (DMPK) studies to track the fate of drug candidates in biological systems using mass spectrometry.
• Internal Standard for Bioanalysis: Serves as a critical, isotopically-labeled internal standard in LC-MS/MS methods for accurate quantification of active pharmaceutical ingredients (APIs) in biological matrices.
• Mechanistic Probe: Facilitates the study of metabolic pathways and the investigation of isotope effects in medicinal chemistry programs.
• Pre-clinical Research: Supports discovery and pre-clinical development phases for potential therapies targeting neurological and psychiatric disorders.
• Reference Standard: Used as a certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	Diethyl-(6-Chloro1,2,3,4-Tetrahydro-2-Carbazolyl)Methyl-D3 Malonate
CAS No.	1189709-87-2
Molecular Formula	C20H20D3ClNO4
Molecular Weight	~380.88 g/mol
Synonyms	Diethyl (6-Chloro-1,2,3,4-tetrahydro-2-carbazolyl)methyl-d3 Malonate; Diethyl [(6-Chloro-1,2,3,4-tetrahydro-2-carbazolyl)methyl-d3]propanedioate; 2-Carbazolylmethyl-d3 Malonic Acid Diethyl Ester (6-Chloro-1,2,3,4-tetrahydro-); Deuterated Carbazole Malonate Ester; D3-Labeled Carbazole Intermediate; 1189709-87-2; (6-Chloro-1,2,3,4-tetrahydro-2-carbazolyl)methyl-d3 Malonic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our Diethyl-(6-Chloro1,2,3,4-Tetrahydro-2-Carbazolyl)Methyl-D3 Malonate is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic purity (D-enrichment), and identity confirmation via advanced spectroscopic techniques. We adhere to cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect this moisture-sensitive material from atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.