Description

2-Phenylbutyric Acid-D5 is a stable isotope-labeled analog of 2-phenylbutyric acid, where five hydrogen atoms are replaced by deuterium. This high-purity compound is essential as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reliability. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical service providers for drug metabolism and pharmacokinetic (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of 2-phenylbutyric acid and related metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) research to track and measure parent drugs and their metabolites.
• Bioanalytical Method Development & Validation: Serves as a key reference material for developing robust, sensitive, and specific analytical methods in compliance with FDA and EMA guidelines.
• Clinical Research & Therapeutic Drug Monitoring: Enables accurate measurement of drug concentrations in patient samples during clinical trials and therapeutic monitoring.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy analytical techniques to minimize matrix effects and improve measurement precision.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradants in active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Phenylbutyric Acid-D5
CAS No.	1189708-92-6
Molecular Formula	C10D5H5O2
Molecular Weight	169.22 g/mol (for C10D5H5O2)
Synonyms	2-Phenyl[2,3,4,5,6-D5]butyric Acid; (2-Phenylbutyric Acid)-D5; α-Ethylbenzeneacetic Acid-D5; DL-2-Phenylbutyric Acid-D5; 2-Phenylbutanoic Acid-D5; (±)-2-Phenylbutyric Acid-D5; 2-Ethyl-2-phenylacetic Acid-D5; Benzeneacetic Acid, α-ethyl-, D5-labeled
EINECS	Contact for details

Quality Control

Every batch of 2-Phenylbutyric Acid-D5 is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical research. Comprehensive testing includes assay, isotopic enrichment (D-content), and identification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.