Description

Diethyl 4-Ethoxyphenyl-(Ethyl-D5)Malonate is a high-purity, deuterium-labeled derivative of a malonate ester, serving as a critical advanced intermediate in pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled building block, enabling precise metabolic and pharmacokinetic studies for new drug candidates. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those developing active pharmaceutical ingredients (APIs) where deuterium incorporation is used to modify drug metabolism and improve therapeutic profiles.

Application

• Pharmaceutical Intermediate: A key deuterated synthon for the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting improved metabolic stability.
• Metabolic Tracer: Used in drug discovery and development as a stable isotope-labeled standard for mass spectrometry-based bioanalytical studies and pharmacokinetic (PK) profiling.
• Deuterium Chemistry: Serves as a specialized building block in medicinal chemistry for the strategic incorporation of deuterium atoms into lead compounds.
• Reference Standard: Employed as an analytical standard for quality control and method validation in the production of deuterated pharmaceuticals.
• Organic Synthesis Research: Utilized in academic and industrial R&D for exploring new synthetic pathways involving functionalized malonate esters.

Basic Information

Product Name	Diethyl 4-Ethoxyphenyl-(Ethyl-D5)Malonate
CAS No.	1189708-84-6
Molecular Formula	C16H17D5O5
Molecular Weight	299.36 g/mol (approx.)
Synonyms	Diethyl (4-ethoxyphenyl)(1,1,2,2,2-pentadeuteroethyl)propanedioate; Diethyl (4-ethoxyphenyl)(ethyl-d5)malonate; (Ethyl-d5)Diethyl 4-ethoxyphenylmalonate; Propanedioic acid, (4-ethoxyphenyl)(1,1,2,2,2-pentadeuteroethyl)-, 1,3-diethyl ester; Deuterated Diethyl 4-Ethoxyphenylmalonate; Diethyl 4-Ethoxyphenyl-(Ethyl-d5)malonate
EINECS	Contact for details

Quality Control

Our Diethyl 4-Ethoxyphenyl-(Ethyl-D5)Malonate is manufactured under strict quality systems to ensure high chemical and isotopic purity suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay (by HPLC or NMR), deuterium enrichment, and impurity profile. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuterium Enrichment (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.