Description

Ethosuximide-D3 is a deuterium-labeled analog of the established anticonvulsant ethosuximide, specifically designed for use as an internal standard in quantitative analytical methods. This stable isotope-labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic studies, drug metabolism research, and therapeutic drug monitoring. It is a critical tool for analytical laboratories and research institutions in the pharmaceutical and life sciences sectors requiring high-precision mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in Liquid Chromatography-Tandem Mass Spectrometry for bioanalysis.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking and quantification of unlabeled ethosuximide in biological matrices (plasma, serum, urine).
• Therapeutic Drug Monitoring (TDM): Used in the development and validation of robust clinical assays to monitor patient drug levels.
• Drug Impurity and Degradation Profiling: Assists in the identification and quantification of related substances in active pharmaceutical ingredient (API) batches.
• Forensic and Toxicology Analysis: Provides a reliable standard for confirmatory testing in forensic investigations.
• Research and Method Development: Serves as a key reagent for scientists developing new analytical protocols for antiepileptic drugs.

Basic Information

Product Name	Ethosuximide-D3
CAS No.	1189703-33-0
Molecular Formula	C7H8D3NO2
Molecular Weight	144.18 g/mol (for C7H8D3NO2)
Synonyms	(±)-3-Ethyl-3-methyl-2,5-pyrrolidinedione-d3; 3-Ethyl-3-methylpyrrolidine-2,5-dione-d3; Ethosuximide (methyl-d3); Ethosuximide-d3; Deuterated Ethosuximide; Ethosuximide Internal Standard; 2,5-Pyrrolidinedione, 3-ethyl-3-methyl-, d3-; Ethosuximide (ethyl-d3) [Note: Specify labeling position upon inquiry]
EINECS	Contact for details

Quality Control

Our Ethosuximide-D3 is manufactured under controlled conditions to ensure high chemical and isotopic purity, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic enrichment, and residual solvents. We adhere to stringent quality management protocols to guarantee batch-to-batch consistency and reliability for your sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D (Typical)
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.