Description

4-[4-(Diphenylmethoxy-D5)-1-Piperidinyl]-1-[4-[(2-Hydroxy-1,1-Dimethyl)Ethyl]Phenyl]Butyne is a high-purity, deuterated chemical reference standard designed for advanced analytical and research applications. This compound is critical for ensuring accuracy and reliability in quantitative analysis, particularly in pharmacokinetic and metabolic studies where precise measurement is paramount. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers requiring stable isotope-labeled internal standards for mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the accurate quantification of its non-deuterated counterpart or related metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to track drug absorption, distribution, metabolism, and excretion (ADME) with high precision.
• Bioanalytical Method Development: Essential for developing and validating robust, sensitive, and specific analytical methods in compliance with FDA and ICH guidelines.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and clinical trial sample analysis where method accuracy and reproducibility are non-negotiable.
• Metabolite Identification: Aids in the structural elucidation and quantification of drug metabolites using high-resolution mass spectrometry.
• Quality Control in API Manufacturing: Can be employed as a reference material to monitor the synthesis and purity of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-[4-(Diphenylmethoxy-D5)-1-Piperidinyl]-1-[4-[(2-Hydroxy-1,1-Dimethyl)Ethyl]Phenyl]Butyne
CAS No.	1189696-09-0
Molecular Formula	C31H31D5NO2
Molecular Weight	457.66 g/mol
Synonyms	Desloratadine-d5; Desloratadine (phenyl-d5); 4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-(4-hydroxymethyl-4-methylpentyl)benzene; 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine-d5; DLRT-d5; Descarboethoxyloratadine-d5
EINECS	Contact for details

Quality Control

Every batch of our 4-[4-(Diphenylmethoxy-D5)-1-Piperidinyl]-1-[4-[(2-Hy droxy-1,1-Dimethyl)Ethyl]Phenyl]Butyne is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing performed using advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98%), isotopic enrichment (typically ≥98 atom % D), and the absence of critical impurities. Our quality commitment ensures the material is suitable for the most demanding regulatory and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.