Description

n-(1-Naphthyl-D7-Methyl)Methylamine is a deuterium-labeled derivative of a naphthylmethylamine compound, specifically designed for advanced research and analytical applications. This high-purity labeled compound is essential for use as an internal standard in mass spectrometry, enabling precise quantification and reliable metabolic studies. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) engaged in drug development, pharmacokinetics, and bioanalytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference standard for the accurate quantification of its non-deuterated counterpart in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in tracing and analyzing the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical compounds.
• Bioanalytical Method Development: Essential for developing and validating robust, sensitive, and specific analytical methods in compliance with FDA and ICH guidelines.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision analytical techniques to achieve superior accuracy and minimize matrix effects.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradation products during drug substance manufacturing.
• Clinical Research: Supports biomarker analysis and therapeutic drug monitoring (TDM) in clinical trial samples.

Basic Information

Product Name	n-(1-Naphthyl-D7-Methyl)Methylamine
CAS No.	1189686-07-4
Molecular Formula	C₁₂H₅D₇N
Molecular Weight	~185.28 g/mol
Synonyms	1-[(Methyl-D3-amino)methyl-D4]naphthalene; N-Methyl-1-naphthalenemethanamine-D7; (1-Naphthyl-D7-methyl)methylamine; Deuterated N-Methyl-1-naphthylmethylamine; N-Methyl-1-naphthylmethylamine-d7; N-Methyl(1-naphthylmethyl)amine-D7; 1-(Aminomethyl-D4)(methyl-D3)naphthalene
EINECS	Contact for details

Quality Control

Every batch of n-(1-Naphthyl-D7-Methyl)Methylamine is manufactured and controlled under a strict quality management system. We guarantee high chemical and isotopic purity, verified by advanced analytical techniques including NMR (¹H, ¹³C) and mass spectrometry. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for identity, purity (HPLC), isotopic enrichment (D%), and other critical parameters to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a cool, dry, and well-ventilated place. For long-term storage under inert atmosphere, sealing under argon or nitrogen is recommended to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.