Description

(2Rs,3Rs)-3-(2-Ethoxy-D5-Phenoxy)-2-Mesyloxy-3-Phenyl-1-Propanol is a high-purity, deuterated chiral intermediate of significant importance in advanced pharmaceutical research and development. Its precise stereochemistry and isotopic labeling make it a critical building block for the synthesis of novel drug candidates, particularly in the fields of neuroscience and metabolic disorders. This compound is essential for medicinal chemists and process development scientists working on deuterium-labeled active pharmaceutical ingredients (APIs) to enhance metabolic stability and pharmacokinetic profiles.

Application

• Deuterated API Synthesis: A key chiral intermediate for the production of deuterium-labeled pharmaceutical compounds.
• Metabolic Stability Studies: Used in the development of drug candidates with improved metabolic profiles and reduced clearance rates.
• Isotopic Labeling Research: Serves as a precursor in the synthesis of compounds for mass spectrometry-based bioanalytical studies and tracer applications.
• Neurological Drug Discovery: Applied in the R&D pathways for potential treatments targeting CNS disorders.
• Process Chemistry & Scale-up: Utilized in route scouting and optimization for the commercial manufacturing of specialty chiral molecules.
• Reference Standard: Can be qualified for use as an analytical reference standard in quality control laboratories.

Basic Information

Product Name	(2Rs,3Rs)-3-(2-Ethoxy-D5-Phenoxy)-2-Mesyloxy-3-Phenyl-1-Propanol
CAS No.	1189680-85-0
Molecular Formula	C18H17D5O5S
Molecular Weight	367.48 g/mol
Synonyms	1-Propanol, 3-(2-ethoxy-2,3,4,5,6-pentadeuteriophenoxy)-2-(methylsulfonyloxy)-3-phenyl-, (2R,3R)-; (2R,3R)-3-(2-Ethoxy-2,3,4,5,6-pentadeuteriophenoxy)-2-(methylsulfonyloxy)-3-phenyl-1-propanol; Deuterated Chiral Mesylate Ester; (2R,3R)-2-Mesyloxy-3-(2-ethoxy-D5-phenoxy)-3-phenylpropan-1-ol; 3-Phenyl-3-(2-ethoxy-D5-phenoxy)-2-mesyloxy-1-propanol, (2R,3R)-; D5-labeled Chiral Propanol Derivative
EINECS	Contact for details

Quality Control

Our (2Rs,3Rs)-3-(2-Ethoxy-D5-Phenoxy)-2-Mesyloxy-3-Phenyl-1-Propanol is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, suitable for research and development applications. We provide comprehensive analytical data including chiral purity, isotopic enrichment (D5), and impurity profiling via advanced techniques like HPLC and NMR. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Isotopic Enrichment (D5, MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.