Description

4-Acetoxynisoldipine-D6 is a deuterium-labeled isotopologue of a key pharmaceutical intermediate. This high-purity compound is essential for quantitative bioanalytical studies, providing an internal standard for the accurate measurement of its non-deuterated counterpart in complex biological matrices. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug metabolism and pharmacokinetics (DMPK) research, analytical method development, and quality control for cardiovascular drug candidates.

Application

• Internal standard for the quantification of Nisoldipine and related metabolites in bioanalytical assays using LC-MS/MS.
• Critical reagent in Drug Metabolism and Pharmacokinetics (DMPK) studies for cardiovascular research programs.
• Use in the development and validation of high-sensitivity analytical methods in pharmaceutical R&D.
• Application in stability studies and impurity profiling of active pharmaceutical ingredients (APIs).
• Tool compound for isotopic dilution analysis to ensure accuracy and precision in clinical and pre-clinical trials.

Basic Information

Product Name	4-Acetoxynisoldipine-D6
CAS No.	1189672-21-6
Molecular Formula	C26H30D6N2O7
Molecular Weight	~494.6 g/mol
Synonyms	Nisoldipine-d6 Acetate; 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester-d6, 4-Acetoxy Derivative; 4-Acetyloxynisoldipine-d6; Deuterated 4-Acetoxynisoldipine; Isotopically Labeled Nisoldipine Intermediate; Bay k 5552-d6 derivative
EINECS	Contact for details

Quality Control

Every batch of 4-Acetoxynisoldipine-D6 is manufactured and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, isotopic enrichment, and solvent residues is provided with each shipment to ensure traceability and compliance with your research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.