Description

Chlorguanide-D4 Hydrochloride is a deuterated isotopologue of the antimalarial drug proguanil, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is of critical importance for use as an internal standard in quantitative bioanalytical methods, ensuring high accuracy and precision in mass spectrometry-based assays. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, clinical trial analysis, and forensic toxicology.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in the quantitative analysis of proguanil and its metabolites in biological matrices (plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Drug Metabolism Studies (DMPK): Used in pharmaceutical R&D to track the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug, enabling precise pharmacokinetic modeling.
• Clinical Trial Support: Ensures data integrity and regulatory compliance in bioanalytical assays conducted during clinical phases for antimalarial drug development.
• Forensic and Anti-Doping Analysis: Provides a reliable isotopic standard for the confirmatory testing of proguanil in forensic toxicology and sports anti-doping control.
• Method Development and Validation: Essential for developing, optimizing, and validating robust, GLP-compliant analytical methods in regulated laboratory environments.

Basic Information

Product Name	Chlorguanide-D4 Hydrochloride
CAS No.	1189671-34-8
Molecular Formula	C11H12D4ClN5•HCl
Molecular Weight	292.22 g/mol
Synonyms	Proguanil-d4 Hydrochloride; 1-(4-Chlorophenyl)-2-(N1-dideuterio-N5-dideuteriobiguanido)propane Dihydrochloride; Chloroguanide-D4 HCl; Bigumal-d4 Hydrochloride; Paludrine-d4 (labeled); N1-para-Chlorophenyl-N5-isopropylbiguanide-d4 Dihydrochloride; NSC 3061-d4 (labeled)
EINECS	Contact for details

Quality Control

Our Chlorguanide-D4 Hydrochloride is manufactured under controlled conditions to meet the exacting standards of analytical and pharmaceutical research. Each batch undergoes rigorous quality testing, including isotopic purity (D-enrichment) verification by NMR and mass spectrometry, chemical purity assessment by HPLC, and identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with internal quality standards and customer requirements for regulated use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.