Description

5-(2-Bromoethyl-D4)-2,3-Dihydrobenzofuran is a high-purity, deuterium-labeled organic intermediate of significant importance in advanced chemical synthesis and research. This compound is specifically valued for its role as a stable isotope-labeled building block, enabling precise metabolic and pharmacokinetic studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and for use as an internal standard in sophisticated analytical methods such as LC-MS.

Application

• Pharmaceutical Research & Development: A critical deuterated intermediate for synthesizing isotopically labeled drug candidates and metabolites for pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies.
• Analytical Chemistry: Employed as a high-purity internal standard in quantitative mass spectrometry (LC-MS, GC-MS) to ensure accuracy and reliability in bioanalytical assays.
• Metabolic Pathway Tracing: Used in mechanistic studies to trace biochemical pathways and understand drug metabolism without interference from endogenous compounds.
• Organic Synthesis Building Block: Serves as a specialized precursor for the synthesis of more complex deuterium-labeled molecules in medicinal and process chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical and biotechnology industries with labeled compound synthesis.

Basic Information

Product Name	5-(2-Bromoethyl-D4)-2,3-Dihydrobenzofuran
CAS No.	1189652-25-2
Molecular Formula	C10H7D4BrO
Molecular Weight	231.12 g/mol
Synonyms	2,3-Dihydro-5-(2-bromoethyl-d4)benzofuran; 5-(2-Bromo-1,1,2,2-tetradeuteroethyl)-2,3-dihydrobenzofuran; 2,3-Dihydro-5-(2-bromo-1,1,2,2-tetradeuteroethyl)benzofuran; Deuterated 5-(2-Bromoethyl)-2,3-dihydrobenzofuran; 5-(2-Bromoethyl-d4)-2,3-dihydrobenzofuran; Tetradeutero-5-(2-bromoethyl)benzofuran
EINECS	Contact for details

Quality Control

Every batch of 5-(2-Bromoethyl-D4)-2,3-Dihydrobenzofuran is manufactured and tested under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including NMR (¹H, ¹³C) and mass spectrometry to confirm deuteration level and chemical identity, as well as HPLC for chemical purity assessment. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Deuteration Degree (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.