Description

Candesartan-D5 CAS NO 1189650-58-5 is a stable isotope-labeled analog of the angiotensin II receptor antagonist Candesartan, where five hydrogen atoms are replaced by deuterium. This compound is a critical internal standard used in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control units involved in the development and analysis of cardiovascular therapeutics.

Application

• Bioanalytical Reference Standard: Serves as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of Candesartan in biological matrices like plasma and serum.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Pharmaceutical Quality Control: Used in validated analytical methods to ensure the potency and purity of Candesartan-based drug products during manufacturing.
• Clinical Research: Facilitates reliable therapeutic drug monitoring and bioequivalence studies for generic drug development.
• Metabolite Identification: Aids in the structural elucidation of drug metabolites using mass spectrometry due to its predictable isotopic pattern.

Basic Information

Product Name	Candesartan-D5
CAS No.	1189650-58-5
Molecular Formula	C24H15D5N6O3
Molecular Weight	425.46 g/mol
Synonyms	Candesartan-d5; 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic Acid-d5; (±)-1-Hydroxyethyl 1-(Candesartan-d5); TCV-116-d5; CV-11974-d5; BLOPRESS-d5; ATACAND-d5; (1-Hydroxyethyl) Candesartan-d5
EINECS	Contact for details

Quality Control

Our Candesartan-D5 is manufactured under strict quality systems to ensure it meets the exacting requirements for use as a certified reference material. Each batch is subjected to rigorous analytical testing, including NMR, HPLC, and Mass Spectrometry, to confirm isotopic purity, chemical purity, and structural identity. A comprehensive Certificate of Analysis (COA) is provided, detailing batch-specific results. Our quality commitment aligns with the standards expected for pharmaceutical R&D and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.