Description

2-(1-Amino-1-Methylethyl)-n-(4-Fluorobenzyl)-5-Hydroxy-1-Methyl-6-Oxo-1,6-Dihydropyrimidine-4-Carboxamide-D3 is a high-purity, deuterated pyrimidine carboxamide derivative, serving as a critical stable isotope-labeled reference standard and synthetic intermediate. Its value lies in enabling precise analytical quantification and metabolic studies in pharmaceutical research and development. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced chemical synthesis sectors who require isotopically labeled materials for drug discovery, pharmacokinetics, and bioanalytical method development.

Application

• Pharmaceutical Reference Standard: Used as a certified internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of its non-deuterated counterpart in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for tracing absorption, distribution, metabolism, and excretion (ADME) pathways in preclinical and clinical research due to its isotopic label.
• Active Pharmaceutical Ingredient (API) Synthesis: Acts as a deuterated building block in the synthesis of novel drug candidates, potentially altering metabolic profiles and improving drug stability.
• Biochemical Research: Employed in mechanistic studies to investigate enzyme interactions and metabolic pathways involving pyrimidine-based compounds.
• Quality Control & Assurance: Serves as a critical tool for validating analytical methods and ensuring batch-to-batch consistency in API manufacturing.

Basic Information

Product Name	2-(1-Amino-1-Methylethyl)-n-(4-Fluorobenzyl)-5-Hydroxy-1-Methyl-6-Oxo-1,6-Dihydropyrimidine-4-Carboxamide-D3
CAS No.	1189508-85-7
Molecular Formula	C₁₇H₁₉D₃FN₄O₃
Molecular Weight	348.39 g/mol
Synonyms	2-(1-Amino-1-methylethyl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide-d3; Deuterated Pyrimidine Carboxamide; 4-Fluorobenzyl-d3 Carboxamide Derivative; (4-Fluorobenzyl)-D3 Carboxamide Intermediate; 1,6-Dihydropyrimidine-4-carboxamide-d3; Stable Isotope Labeled API Intermediate; [D3]-Labeled Pyrimidine; CAS 1189508-85-7
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C), High-Resolution Mass Spectrometry (HRMS), and HPLC to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support compliance with cGMP and ISO guidelines for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., argon or nitrogen) after opening to prevent degradation. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.