Description

Sodium:3,3-Dideuterio-2-Oxobutanoate is a deuterium-labeled derivative of sodium 2-oxobutanoate, a key intermediate in metabolic pathways. This compound is specifically designed for use as a stable isotope-labeled internal standard in advanced analytical chemistry, enabling precise quantification and metabolic tracing. It is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and agrochemical sectors who require high-fidelity analytical standards for mass spectrometry (LC-MS, GC-MS) and NMR studies.

Application

• Internal Standard for Mass Spectrometry: Used as a deuterated standard for the accurate quantification of 2-oxobutanoate and related metabolites in complex biological matrices via LC-MS or GC-MS.
• Metabolic Pathway Research: Employed in tracer studies to investigate the Krebs cycle, amino acid metabolism, and other biochemical pathways in both in vitro and in vivo systems.
• Pharmaceutical Development & Bioanalysis: Critical for pharmacokinetic (PK) and pharmacodynamic (PD) studies, ensuring accurate measurement of drug metabolites in preclinical and clinical research.
• Diagnostic Assay Development: Serves as a calibrant or reference material in the development of clinical diagnostic tests for metabolic disorders.
• Isotope Labeling & Chemical Synthesis: Acts as a building block for the synthesis of more complex deuterium-labeled compounds for research purposes.
• Quality Control & Method Validation: Provides a reliable reference standard for validating analytical methods in compliance with GLP and GMP guidelines.

Basic Information

Product Name	Sodium:3,3-Dideuterio-2-Oxobutanoate
CAS No.	1189500-69-3
Molecular Formula	C4H3D2NaO3
Molecular Weight	130.07 g/mol (approx.)
Synonyms	Sodium 3,3-dideutero-2-oxobutanoate; Sodium 2-Oxobutyrate-3,3-d2; 2-Oxobutyric Acid-3,3-d2 Sodium Salt; 3,3-Dideuterio-2-oxobutanoic Acid Sodium Salt; α-Ketobutyric Acid-d2 Sodium Salt; Sodium α-Ketobutyrate-d2; 2-Ketobutyric Acid-d2 Sodium Salt; Sodium 2-Ketobutyrate-3,3-d2
EINECS	Contact for details

Quality Control

Our Sodium:3,3-Dideuterio-2-Oxobutanoate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and batch-to-batch consistency, meeting the stringent requirements for research and analytical applications. Certificates of Analysis (COA) providing detailed specifications for identity, purity (by HPLC/NMR), isotopic purity (D-enrichment), and residual solvents are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.