Description

8-Chloro-3-Methoxy-11-(1-Methyl-4-Piperidinyl)-6,11-Dihydro-5H-Benzo[5,6]-Cyclohepta[1,2-B]Pyridin-11-Ol-D4 is a deuterated isotopologue of a key pharmaceutical intermediate, offering enhanced metabolic stability and traceability for advanced research and development. This compound is critical for the synthesis of deuterated drug candidates, particularly in the development of novel antihistamines and central nervous system (CNS) agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and advanced material scientists focused on pharmacokinetic studies and the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of deuterated analogs of loratadine, desloratadine, and related tricyclic antihistamines.
• Metabolic Stability Studies: Used in drug discovery to create isotopically labeled compounds for investigating absorption, distribution, metabolism, and excretion (ADME) profiles.
• Internal Standard for Bioanalysis: Serves as a high-purity reference standard in Liquid Chromatography-Mass Spectrometry (LC-MS) for accurate quantification of drugs in biological matrices.
• Mechanistic Research: Enables detailed study of metabolic pathways and enzyme kinetics due to the kinetic isotope effect (KIE) imparted by deuterium atoms.
• Process Chemistry & Scale-up: Supports the development and optimization of synthetic routes for deuterated Active Pharmaceutical Ingredients (APIs).
• Regulatory Submissions: Provides essential material for preclinical and clinical studies required for regulatory filings of deuterated drug products.

Basic Information

Product Name	8-Chloro-3-Methoxy-11-(1-Methyl-4-Piperidinyl)-6,11-Dihydro-5H-Benzo[5,6]-Cyclohepta[1,2-B]Pyridin-11-Ol-D4
CAS No.	1189492-69-0
Molecular Formula	C22H22D4ClN2O2
Molecular Weight	389.93 g/mol (deuterated form)
Synonyms	Desloratadine-d4; Descarboethoxyloratadine-d4; 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine-3-carbonitrile-d4 (related structure); Loratadine Metabolite-d4; SCH 34117-d4; 11-Hydroxy Loratadine-d4; Deuterated Tricyclic Antihistamine Intermediate
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical and synthetic applications. Each batch is characterized by advanced spectroscopic techniques including NMR (¹H, ¹³C) and High-Resolution Mass Spectrometry (HRMS) to confirm deuteration level and structural identity. Certificates of Analysis (COA) detailing purity (by HPLC), isotopic enrichment (D-content), and full analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under an inert atmosphere at 2-8°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.