Description

Cicletanine-D4 Hydrochloride is a deuterated isotopologue of the diuretic agent Cicletanine, specifically labeled with four deuterium atoms. This high-purity reference standard is critical for ensuring accuracy and reliability in quantitative analytical methods, particularly in pharmaceutical research and development. It is primarily utilized by analytical chemists and researchers in the pharmaceutical and contract research organization (CRO) sectors for use as an internal standard in LC-MS/MS and GC-MS assays, enabling precise pharmacokinetic and metabolic studies.

Application

• Internal Standard for Bioanalysis: Serves as a stable isotope-labeled internal standard in the quantitative determination of Cicletanine in biological matrices (plasma, serum, urine) via LC-MS/MS or GC-MS, improving assay precision and accuracy.
• Pharmacokinetic & Metabolism Studies: Essential for conducting advanced ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the drug's behavior in the body.
• Method Development & Validation: Used in the development and validation of robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Pharmaceutical Quality Control: Employed as a reference material in impurity profiling and assay development for drug substance and product quality control.
• Clinical Research: Supports clinical trial sample analysis to ensure reliable data for regulatory submissions.
• Isotope Dilution Mass Spectrometry (IDMS): A key component in high-precision IDMS techniques for absolute quantification.

Basic Information

Product Name	Cicletanine-D4 Hydrochloride
CAS No.	1189491-41-5
Molecular Formula	C22H19D4Cl2NO3
Molecular Weight	424.35 g/mol (approx.)
Synonyms	3-(4-Chlorophenyl)-1,3-dihydro-6-(methyl-d3)-7-(1-methylethyl-d)-2H-furo[3,4-c]pyridin-2-one Hydrochloride; Cicletanine (methyl-d3, isopropyl-d) Hydrochloride; Cicletanine-d4 HCl; Deuterated Cicletanine Hydrochloride; 6-(Methyl-d3)-7-(1-methylethyl-d)-3-(4-chlorophenyl)-1,3-dihydrofuro[3,4-c]pyridin-2-one Hydrochloride
EINECS	Contact for details

Quality Control

Our Cicletanine-D4 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity. Each batch is supplied with a comprehensive Certificate of Analysis (COA) detailing results for assay, isotopic enrichment (D4), and purity by HPLC. We adhere to strict quality management protocols suitable for research and development use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D4)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.