Description

1,6-Dihydro-5-Hydroxy-1-Methyl-2-[1-Methyl-1-[[Benzylcarbamoyl]Amino]Ethyl]-6-Oxo-4-Pyrimidinecarboxylic Acid Methyl Ester-D3 is a deuterated pyrimidine derivative, a high-value intermediate of significant interest in advanced pharmaceutical research and development. Its core value lies in its utility as a stable isotope-labeled compound, which is essential for pharmacokinetic, metabolic, and bioanalytical studies, enhancing the precision and reliability of data. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel drug candidates, particularly those requiring deuterium incorporation for improved metabolic stability or as internal standards for mass spectrometry.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of deuterated active pharmaceutical ingredients (APIs) for new chemical entities.
• Metabolic Tracer: Used in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of drug molecules within biological systems.
• Internal Standard for LC-MS/MS: Employed as a high-purity, isotopically labeled internal standard in quantitative bioanalytical methods, ensuring accurate and reproducible results.
• Medicinal Chemistry Research: Facilitates structure-activity relationship (SAR) studies by providing a deuterated analog to investigate isotope effects on drug potency and metabolic profile.
• Process Chemistry Development: Used in route scouting and optimization for the scalable synthesis of deuterium-labeled compounds.
• Reference Standard: Acts as an analytical reference standard for quality control and regulatory submissions of deuterated pharmaceuticals.

Basic Information

Product Name	1,6-Dihydro-5-Hydroxy-1-Methyl-2-[1-Methyl-1-[[Benzylcarbamoyl]Amino]Ethyl]-6-Oxo-4-Pyrimidinecarboxylic Acid Methyl Ester-D3
CAS No.	1189485-35-5
Molecular Formula	C18H21D3N3O5
Molecular Weight	Contact for details
Synonyms	Deuterated Pyrimidinecarboxylic Acid Ester; Methyl 1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[(phenylmethyl)carbamoyl]amino]ethyl]-6-oxo-4-pyrimidinecarboxylate-d3; 4-Pyrimidinecarboxylic acid, 1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(phenylmethyl)amino]carbonyl]amino]ethyl]-6-oxo-, methyl ester-d3; Deuterated API Intermediate; Isotopically Labeled Pyrimidine Derivative; D3-Labeled Benzylcarbamoyl Pyrimidine Ester
EINECS	Contact for details

Quality Control

Our 1,6-Dihydro-5-Hydroxy-1-Methyl-2-[1-Methyl-1-[[Benzylcarbamoyl]Amino]Ethyl]-6-Oxo-4-Pyrimidinecarboxylic Acid Methyl Ester-D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and isotopic enrichment, to ensure compliance with exacting customer specifications and research-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and deuterium content are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.