Description

2-[2-[4-[(4-Chlorophenyl)-Phenylmethyl]-2,2,3,3,5,5,6,6-Octadeuteriopiperazin-1-Yl]Ethoxy]Ethanol is a deuterated derivative of a piperazine-based compound, offering enhanced metabolic stability and traceability in research applications. This high-value specialty chemical is critical for pharmaceutical development, particularly in the creation of deuterated drug candidates and as an internal standard in analytical methods. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract research organizations (CROs) focused on advanced medicinal chemistry and pharmacokinetic studies.

Application

• Pharmaceutical Research & Development: As a deuterated building block for synthesizing novel drug candidates with improved metabolic profiles (Deuterated Drug Discovery).
• Analytical Chemistry: Serving as a stable isotope-labeled internal standard for precise quantification in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis.
• Metabolite Identification & Pharmacokinetics (PK/PD): Used in tracer studies to investigate drug metabolism pathways and absorption, distribution, metabolism, and excretion (ADME) properties.
• Biochemical Research: As a tool compound in receptor binding assays and mechanistic studies within neuropharmacology and related fields.
• Process Chemistry & Scale-up: Supporting the development and optimization of synthetic routes for complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-[2-[4-[(4-Chlorophenyl)-Phenylmethyl]-2,2,3,3,5,5,6,6-Octadeuteriopiperazin-1-Yl]Ethoxy]Ethanol
CAS No.	1189480-47-4
Molecular Formula	C21H19D8ClN2O2
Molecular Weight	~389.95 g/mol (deuterated form)
Synonyms	2-{2-[4-(4-Chloro-α-phenylbenzyl)-2,2,3,3,5,5,6,6-octadeuterio-1-piperazinyl]ethoxy}ethanol; Deuterated Cetirizine Intermediate; Octadeuterio-piperazine ethanol derivative; 4-[(4-Chlorophenyl)phenylmethyl]-1-[2-(2-hydroxyethoxy)ethyl]-2,2,3,3,5,5,6,6-octadeuteriopiperazine; D8-Cetirizine Related Compound; (4-Chlorophenyl)(phenyl)methyl D8-piperazinyl ethoxyethanol
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure high isotopic purity and chemical integrity, essential for research reproducibility. Each batch is characterized using advanced analytical techniques including NMR (¹H, ²H, ¹³C) and High-Resolution Mass Spectrometry (HRMS). Certificates of Analysis (COA) detailing isotopic enrichment (D-content), chemical purity, and identity are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.