Description

4-(1,1,2,2,3,3,4,4,4-Nonadeuteriobutyl)-1,2-Diphenylpyrazolidine-3,5-Dione is a high-purity deuterated derivative of a pyrazolidinedione core structure, offering a stable isotopic label for advanced research and development. This compound is specifically engineered to serve as a critical internal standard or tracer in analytical chemistry, enabling precise quantification and metabolic pathway studies. It is essential for pharmaceutical R&D, analytical laboratories, and academic institutions engaged in pharmacokinetics, drug metabolism, and stable isotope labeling applications.

Application

• Pharmaceutical Research & Development: Used as a stable isotope-labeled internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate bioanalysis of drugs and metabolites.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for tracing metabolic pathways, studying absorption, distribution, metabolism, and excretion (ADME) profiles of new chemical entities.
• Analytical Method Development: Enhances the precision and reliability of quantitative analytical methods in compliance with Good Laboratory Practice (GLP) and other regulatory guidelines.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-accuracy quantification techniques to minimize matrix effects and improve analytical results.
• Chemical Reference Standard: Serves as a certified reference material for quality control and assurance in pharmaceutical manufacturing and testing laboratories.
• Academic and Institutional Research: Supports fundamental research in medicinal chemistry, organic synthesis, and mechanistic studies where deuterium labeling is required.

Basic Information

Product Name	4-(1,1,2,2,3,3,4,4,4-Nonadeuteriobutyl)-1,2-Diphenylpyrazolidine-3,5-Dione
CAS No.	1189479-75-1
Molecular Formula	C25H21D9N2O2
Molecular Weight	~395.55 g/mol
Synonyms	4-(Nonadeuteriobutyl)-1,2-diphenyl-3,5-pyrazolidinedione; Deuterated Phenylbutazone-d9; 1,2-Diphenyl-4-(1,1,2,2,3,3,4,4,4-nonadeuteriobutyl)pyrazolidine-3,5-dione; Phenylbutazone-d9; Butazolidin-d9; [D9]-Phenylbutazone; 4-(Butyl-d9)-1,2-diphenylpyrazolidine-3,5-dione
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity for research applications. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and Mass Spectrometry to confirm identity, chemical purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment. We support compliance with ISO standards and can tailor specifications to meet the rigorous demands of method validation and regulatory submission.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.