Description

Rac α-Lipoic Acid-D5 CAS NO 1189471-66-6 is a stable isotope-labeled analog of the essential cofactor α-lipoic acid, where five hydrogen atoms are replaced with deuterium. This compound is critical for use as an internal standard in quantitative analytical methods, ensuring high accuracy and reliability in mass spectrometry and other detection techniques. It is primarily required by research institutions, pharmaceutical developers, and analytical laboratories engaged in metabolic studies, pharmacokinetic research, and the quality control of related pharmaceutical products.

Application

• Internal Standard for LC-MS/MS and GC-MS analysis in bioanalytical studies.
• Tracer compound in metabolic pathway and pharmacokinetic (PK/PD) research.
• Reference material for the quantification of endogenous α-lipoic acid in biological matrices.
• Quality control and method validation in pharmaceutical development of lipoic acid-based therapeutics.
• Use in stable isotope dilution assays to ensure precision in clinical diagnostics.
• Research tool in studying the antioxidant mechanisms and mitochondrial function of α-lipoic acid.

Basic Information

Product Name	Rac α-Lipoic Acid-D5
CAS No.	1189471-66-6
Molecular Formula	C8H9D5O2S2
Molecular Weight	209.35 g/mol (for deuterated form)
Synonyms	(±)-α-Lipoic Acid-d5; DL-α-Lipoic Acid-d5; 6,8-Bis(deuteriomethyl)-1,2-dithiolane-3-pentanoic Acid; 5-[3-(1,2-Dithiolan-3-yl)]pentanoic Acid-d5; 1,2-Dithiolane-3-valeric Acid-d5; Thioctic Acid-d5; 6,8-Thioctic Acid-d5; ALA-d5
EINECS	Contact for details

Quality Control

Our Rac α-Lipoic Acid-D5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and Mass Spectrometry, to confirm isotopic purity, chemical purity, and structural identity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.