Description

D,L N,o-Didesmethylvenlafaxine-D3 is a deuterium-labeled internal standard of a key venlafaxine metabolite, essential for precise bioanalytical quantification. This high-purity compound is critical for ensuring accuracy and reliability in pharmacokinetic and metabolic studies, particularly in regulated environments. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in LC-MS/MS method development and validation.

Application

• LC-MS/MS Internal Standard: Serves as a critical deuterated internal standard for the accurate quantification of N,o-didesmethylvenlafaxine and related metabolites in biological matrices (e.g., plasma, serum, urine).
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug metabolism pathways and calculation of pharmacokinetic parameters for venlafaxine and its derivatives.
• Bioanalytical Method Development & Validation: Used as a reference material to develop, optimize, and validate robust, GLP/GCP-compliant analytical methods.
• Forensic & Clinical Toxicology: Supports accurate analysis in forensic investigations and therapeutic drug monitoring (TDM) programs.
• Drug Impurity Profiling & Characterization: Aids in the identification and quantification of process-related impurities or degradation products in active pharmaceutical ingredient (API) batches.
• Stable Isotope Labeling Research: Utilized in research exploring the use of stable isotopes for tracer studies in drug metabolism and disposition.

Basic Information

Product Name	D,L N,o-Didesmethylvenlafaxine-D3
CAS No.	1189468-67-4
Molecular Formula	C15H19D3NO2
Molecular Weight	250.37 g/mol (for monoisotopic mass)
Synonyms	N,o-Didesmethylvenlafaxine-d3; O-Desmethylvenlafaxine-d3 (N-Desmethyl); 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol-d3; N-Desmethyl-O-desmethylvenlafaxine-d3; Didesmethylvenlafaxine-d3; Deuterated N,o-Didesmethylvenlafaxine; Venlafaxine Metabolite-d3; ODV-d3 (N-Desmethyl); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our deuterated reference standards are manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical data is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.