Description

2,6-Di-iso-Propylphenol-D18 is a deuterated analog of propofol, a widely used intravenous anesthetic agent. This stable isotope-labeled compound is essential for advanced analytical research, serving as a critical internal standard for precise quantification. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Serves as a high-purity, stable isotope-labeled internal standard for the accurate quantification of propofol and its metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmacokinetic & Bioavailability Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Drug Metabolism Research (DMPK): Used to investigate metabolic pathways, identify metabolites, and study enzyme kinetics without interference from the endogenous compound.
• Bioanalytical Method Development & Validation: Critical for developing and validating robust, sensitive, and specific analytical methods in compliance with GLP and FDA/EMA guidelines.
• Forensic & Clinical Toxicology: Supports accurate measurement of propofol levels in forensic analysis and therapeutic drug monitoring (TDM).
• Reference Material for Quality Control: Acts as a certified reference material (CRM) for calibrating instruments and ensuring data integrity in analytical laboratories.

Basic Information

Product Name	2,6-Di-iso-Propylphenol-D18
CAS No.	1189467-93-3
Molecular Formula	C12D18O
Molecular Weight	178.33 g/mol
Synonyms	Propofol-d18; 2,6-Bis(1-methylethyl)phenol-d18; 2,6-Diisopropylphenol-d18; Deuterated Propofol; [D18]-Propofol; 2,6-Di(propan-2-yl)phenol-d18; Isoflurane (common misnomer, correct is Propofol-d18)
EINECS	Contact for details

Quality Control

Every batch of 2,6-Di-iso-Propylphenol-D18 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing via NMR, HPLC, and Mass Spectrometry to confirm identity, potency, and deuterium enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.