Description

3-(2,4,5,6-Tetradeuteriopyridine-3-Carbonyl)Piperidin-2-One is a deuterium-labeled organic compound, a key building block in advanced chemical synthesis and research. Its primary value lies in its role as a stable isotope-labeled internal standard, which is critical for ensuring accuracy and reliability in quantitative analytical methods. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for developing and validating mass spectrometry-based assays for drug metabolism and pharmacokinetic (DMPK) studies. The compound, identified by CAS number 1189467-35-3, enables precise tracking and quantification of target molecules in complex biological matrices.

Application

• As a deuterium-labeled internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis.
• Critical component in pharmaceutical research for studying the absorption, distribution, metabolism, and excretion (ADME) of new drug candidates.
• Used in the synthesis of labeled analogs for agrochemical research and environmental fate studies.
• Building block for the development of proteomics and metabolomics research tools and diagnostic assays.
• Essential material in contract research organizations (CROs) and analytical testing laboratories for method development and validation.
• Precursor for synthesizing isotopically labeled compounds used in nuclear magnetic resonance (NMR) spectroscopy as chemical shift references or probes.

Basic Information

Product Name	3-(2,4,5,6-Tetradeuteriopyridine-3-Carbonyl)Piperidin-2-One
CAS No.	1189467-35-3
Molecular Formula	C11H9D4N2O2
Molecular Weight	205.24 g/mol
Synonyms	3-(2,4,5,6-Tetradeuteropyridine-3-carbonyl)piperidin-2-one; 3-(2,4,5,6-Tetradeutero-pyridine-3-carbonyl)-2-piperidinone; 3-(Perdeuterated-pyridine-3-carbonyl)piperidin-2-one (d4); 2-Oxo-1-piperidine-3-carboxylic acid (2,4,5,6-d4)-3-pyridinyl ester; Deuterated Nicotinoyl Piperidinone; 1189467-35-3; (D4)-3-(Pyridine-3-carbonyl)piperidin-2-one
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure isotopic purity and chemical integrity, which are paramount for analytical applications. Each batch is characterized using advanced techniques including NMR, HPLC, and Mass Spectrometry to confirm chemical structure, isotopic enrichment (typically >98 atom % D), and overall purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing assay, purity, and solvent content. Our quality system is designed to meet the rigorous demands of GLP (Good Laboratory Practice) and research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term stability, consider storage under an inert atmosphere such as argon or nitrogen, especially after the container has been opened. Keep the container tightly sealed in a desiccator to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.