Description

4-Amino-N,1-Dimethyl-5-Imidazolecarboxamide-D3 is a deuterium-labeled analog of a key imidazole derivative, serving as a critical stable isotope-labeled internal standard for precise analytical quantification. This high-purity compound is essential for ensuring accuracy and reliability in sensitive mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy applications. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and pharmacokinetics (DMPK) studies.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of its non-labeled counterpart in bioanalytical methods, minimizing matrix effects and improving data precision.
• Drug Metabolism Studies (DMPK): Facilitates tracing and quantifying drug metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Pharmacokinetic Research: Enables precise measurement of absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical compounds.
• Biomarker Analysis: Supports quantitative assays in clinical research for validating potential biomarkers.
• Reference Material: Acts as a certified reference material (CRM) for calibrating analytical instruments and validating method accuracy.
• Synthetic Intermediate: May serve as a building block for the synthesis of more complex deuterium-labeled molecules for research purposes.

Basic Information

Product Name	4-Amino-N,1-Dimethyl-5-Imidazolecarboxamide-D3
CAS No.	1189466-51-0
Molecular Formula	C7H8D3N5O
Molecular Weight	170.19 g/mol
Synonyms	4-Amino-1,5-dimethylimidazole-5-carboxamide-D3; 4-Amino-1,5-dimethyl-1H-imidazole-5-carboxamide-D3; 1,5-Dimethyl-4-aminoimidazole-5-carboxamide-D3; Deuterated 4-Amino-N,1-dimethyl-5-imidazolecarboxamide; [D3]-4-Amino-N,1-dimethyl-5-imidazolecarboxamide; 4-Amino-1,5-dimethyl-1H-imidazole-5-carboxylic acid amide-D3; AICA-D3 (deuterated derivative)
EINECS	Contact for details

Quality Control

This deuterated compound is manufactured under strict quality control protocols to ensure isotopic purity and chemical integrity, critical for its role as an analytical standard. Each batch is characterized using advanced techniques including NMR spectroscopy and high-resolution mass spectrometry (HRMS) to confirm deuteration level and chemical purity. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (e.g., D3, ≥98 atom % D), chemical purity (by HPLC), and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which could affect stability and weighing accuracy. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity (Atom % D)	≥98% (D3)
Chemical Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.