Description

4-Chloro-n-[2-(4-Hydroxyphenyl)Ethyl]Benzamide-D4 is a deuterated analog of a key benzamide derivative, serving as a critical internal standard and reference material for precise analytical quantification. This high-purity compound is essential for ensuring accuracy and reliability in sensitive mass spectrometry and chromatography-based methods. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in method development, pharmacokinetic studies, and metabolite identification.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of the non-deuterated parent compound in complex biological matrices like plasma, serum, and tissue homogenates.
• Pharmaceutical Research & Development: Used in drug metabolism and pharmacokinetics (DMPK) studies, including bioavailability, bioequivalence, and metabolite profiling.
• Analytical Method Development and Validation: A critical component for developing robust, sensitive, and specific HPLC and UPLC methods in compliance with ICH guidelines.
• Clinical Research: Supports therapeutic drug monitoring (TDM) and preclinical/clinical trial sample analysis to ensure data integrity.
• Isotope Dilution Mass Spectrometry (IDMS): Employed as a stable-isotope-labeled tracer for achieving high-precision measurements in quantitative analysis.
• Biomarker Discovery and Validation: Aids in the precise measurement of endogenous or exogenous compounds in proteomic and metabolomic research.

Basic Information

Product Name	4-Chloro-n-[2-(4-Hydroxyphenyl)Ethyl]Benzamide-D4
CAS No.	1189464-84-3
Molecular Formula	C15H10D4ClNO2
Molecular Weight	275.76 g/mol (for deuterated form)
Synonyms	4-Chloro-N-[2-(4-hydroxyphenyl)ethyl]benzamide-d4; 4-Chloro-N-(2-(4-hydroxyphenyl)ethyl)benzamide-d4; Benzamide, 4-chloro-N-[2-(4-hydroxyphenyl)ethyl]-, d4-; Deuterated 4-Chloro-N-(2-(4-hydroxyphenyl)ethyl)benzamide; 4-Chloro-N-(2-(4-Hydroxyphenyl)ethyl)benzamide (phenyl-d4); Stable Isotope Labeled Benzamide Derivative; Internal Standard for 4-Chloro-N-(2-(4-Hydroxyphenyl)ethyl)benzamide
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure exceptional isotopic purity and chemical integrity. Each batch is characterized by advanced analytical techniques including NMR (1H, 13C), High-Resolution Mass Spectrometry (HRMS), and HPLC to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing all specifications are provided and traceable to primary reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the material should be handled in a dry environment and containers must be sealed immediately after use to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Area %)
Chemical Purity (HPLC)	≥95.0%
Isotopic Purity (Deuterium Incorporation)	≥98 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.