Description

5-[[4-[1,1,2,2-Tetradeuterio-2-[5-(2-Methyl-1,3-Dioxolan-2-Yl)Pyridin-2-Yl]Ethoxy]Phenyl]Methyl]-1,3-Thiazolidine-2,4-Dione is a deuterated derivative of a thiazolidinedione-based compound, serving as a critical stable isotope-labeled intermediate. This product is essential for pharmaceutical research and development, particularly in the synthesis of deuterated drug candidates for metabolic and pharmacokinetic (DMPK) studies. It is primarily used by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the development of novel therapeutics, especially in the fields of metabolic disease and oncology.

Application

• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: Key building block for creating deuterium-labeled drug molecules with enhanced metabolic stability.
• Pharmacokinetic and Metabolism Studies (DMPK): Used as an internal standard or precursor in mass spectrometry for accurate quantification and metabolite tracking.
• Drug Discovery Research: Enables the exploration of the deuterium isotope effect to improve the safety and efficacy profiles of lead compounds.
• Reference Standard Production: Serves as a high-purity material for the preparation of certified reference standards (CRS) for analytical method development and validation.
• Isotope Labeling Services: A critical material for custom synthesis and contract manufacturing organizations (CMOs) specializing in labeled compounds.

Basic Information

Product Name	5-[[4-[1,1,2,2-Tetradeuterio-2-[5-(2-Methyl-1,3-Dioxolan-2-Yl)Pyridin-2-Yl]Ethoxy]Phenyl]Methyl]-1,3-Thiazolidine-2,4-Dione
CAS No.	1189460-98-7
Molecular Formula	C21H19D4NO4S
Molecular Weight	~397.50 g/mol
Synonyms	5-[[4-[1,1,2,2-Tetradeutero-2-[5-(2-methyl-1,3-dioxolan-2-yl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione; Deuterated Thiazolidinedione Derivative; 5-[(4-{[1,1,2,2-Tetradeuterio-2-(5-(2-methyl-1,3-dioxolan-2-yl)pyridin-2-yl]ethoxy}phenyl)methyl]thiazolidine-2,4-dione; [D4]-Labeled Thiazolidinedione Intermediate; CAS 1189460-98-7
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical intermediates. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and LC-MS to confirm identity, chemical purity, and isotopic enrichment. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a cGMP-compliant quality management system for traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.