Description

Phenoprolamine-D3 Hydrochloride is a deuterium-labeled analog of phenoprolamine hydrochloride, a compound of significant interest in pharmaceutical research and development. This stable isotope-labeled internal standard is critical for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly Liquid Chromatography-Mass Spectrometry (LC-MS/MS). It is primarily utilized by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in pharmacokinetic studies, drug metabolism research, and clinical trial support for compounds related to the phenoprolamine class.

Application

• Quantitative Bioanalysis: Serves as an essential internal standard in LC-MS/MS assays for the precise quantification of phenoprolamine and its metabolites in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track and quantify the parent drug, improving data accuracy by correcting for instrument variability and matrix effects.
• Clinical Trial Support: Enables reliable therapeutic drug monitoring and pharmacokinetic profiling during clinical development phases.
• Forensic and Doping Control Analysis: Provides a reference standard for confirmatory testing in forensic toxicology and anti-doping laboratories.
• Method Development and Validation: A key component in developing and validating robust, regulatory-compliant analytical methods for new drug applications (NDAs).
• Quality Control in Pharmaceutical Manufacturing: Can be used as a reference standard for in-process testing and final product release of the corresponding non-deuterated active pharmaceutical ingredient (API).

Basic Information

Product Name	Phenoprolamine-D3 Hydrochloride
CAS No.	1189456-69-6
Molecular Formula	C16H20D3ClN2O • HCl
Molecular Weight	~ 329.3 g/mol (for monohydrochloride)
Synonyms	Phenoprolamine-d3 HCl; (R)-N-Methyl-1-phenyl-2-(1-pyrrolidinyl)-1-propanone-d3 Hydrochloride; 1-Phenyl-2-(1-pyrrolidinyl)-1-propanone-d3 Hydrochloride; α-Pyrrolidinopropiophenone-d3 Hydrochloride; α-PPP-d3 HCl; Deuterated Phenoprolamine Hydrochloride; 1-Phenyl-2-(pyrrolidin-1-yl)propan-1-one-d3 Hydrochloride
EINECS	Contact for details

Quality Control

Our Phenoprolamine-D3 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H and ¹³C) and Mass Spectrometry for structural confirmation and isotopic purity verification. Purity is determined via validated HPLC methods. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on chemical purity, isotopic enrichment, and residual solvent content, supporting its use in GLP/GMP-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to maintain stability and purity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.