Description

Loxapine-D8 is a deuterated analog of the antipsychotic agent Loxapine, specifically designed for use as an internal standard in analytical chemistry. This high-purity reference material is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities that require precise measurement of Loxapine and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, isotopically-labeled internal standard for the quantification of Loxapine in biological matrices (plasma, serum, urine) using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic & Bioavailability Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and pre-clinical trials.
• Forensic & Toxicology Analysis: Used in forensic laboratories for the precise identification and quantification of Loxapine in cases of overdose or post-mortem investigations.
• Drug Metabolism Research: Facilitates the study of metabolic pathways and the identification of Loxapine metabolites in vitro and in vivo.
• Quality Control in Pharmaceutical Manufacturing: Serves as a critical reference standard for the assay and impurity profiling of Loxapine active pharmaceutical ingredient (API) and finished dosage forms.
• Method Development & Validation: Essential for developing, optimizing, and validating robust analytical methods in compliance with ICH, FDA, and EMA guidelines.

Basic Information

Product Name	Loxapine-D8
CAS No.	1189455-63-7
Molecular Formula	C18H10D8ClN2O
Molecular Weight	~332.85 g/mol
Synonyms	Loxapine-d8; 2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]oxazepine-d8; Deuterated Loxapine; Loxapine (hexadeutero); Loxapine Internal Standard; Loxitane-d8; Dibenzo[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-, hexadeutero derivative
EINECS	Contact for details

Quality Control

Every batch of Loxapine-D8 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated environments. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as isotopic purity, chemical purity, and residual solvent content. Our quality commitment ensures compliance with the standards expected for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Content)	≥98 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.