Description

2,6-Dichloro-4,8-(Dipiperidino-D20)-Pyrimido[5,4-D]Pyrimidine is a deuterated derivative of a pyrimidopyrimidine scaffold, a compound class of significant interest in medicinal chemistry and advanced materials science. This deuterated compound is specifically designed for use as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in pharmacokinetic and metabolic studies. It is essential for researchers and developers in the pharmaceutical, agrochemical, and life science sectors who require high-fidelity analytical standards for drug discovery and development.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterium-labeled internal standard for the precise quantification of its non-deuterated counterpart in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for studying absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Pharmaceutical Impurity Profiling: Used as a reference standard to identify and quantify process-related impurities and degradants in active pharmaceutical ingredients (APIs).
• Biochemical Research: Serves as a tool compound for investigating enzyme inhibition, receptor binding, and other molecular interactions where isotopic labeling is required.
• Agrochemical Analysis: Employed in the development and validation of analytical methods for novel agrochemical agents.
• Isotope Dilution Mass Spectrometry (IDMS): A key component in high-accuracy analytical techniques for certification of reference materials.

Basic Information

Product Name	2,6-Dichloro-4,8-(Dipiperidino-D20)-Pyrimido[5,4-D]Pyrimidine
CAS No.	1189450-21-2
Molecular Formula	C19H14D20Cl2N6
Molecular Weight	Contact for details
Synonyms	2,6-Dichloro-4,8-dipiperidino-D20-pyrimido[5,4-d]pyrimidine; Dipyridamole-D20 derivative; 4,8-Bis(piperidino-D10)-2,6-dichloropyrimido[5,4-d]pyrimidine; Deuterated Dipyridamole Impurity/Intermediate; [D20]-2,6-Dichloro-4,8-dipiperidinopyrimido[5,4-d]pyrimidine; Perdeuterated Piperidino Pyrimidopyrimidine; Stable Isotope Labeled Pyrimidopyrimidine; CAS 1189450-21-2
EINECS	Contact for details

Quality Control

Every batch of 2,6-Dichloro-4,8-(Dipiperidino-D20)-Pyrimido[5,4-D]Pyrimidine is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity as verified by advanced analytical techniques including NMR (¹H, ¹³C, ²H), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment (D%), and identity is provided with each shipment to ensure compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D%)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.