Description

n-Boc-n-Methylpiperazine-D8 is a deuterated analog of the versatile Boc-protected piperazine building block, specifically designed for advanced research and development. This compound is critical for creating isotopically labeled molecules, which are essential tools in pharmacokinetic, metabolic, and mechanistic studies. It is primarily utilized by pharmaceutical, agrochemical, and academic researchers requiring high-purity, stable isotope-labeled intermediates for drug discovery and analytical method development.

Application

• Pharmaceutical Research: As a deuterated building block for the synthesis of isotopically labeled Active Pharmaceutical Ingredients (APIs) and drug candidates for use in Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) studies.
• Metabolic Studies: Synthesis of internal standards for Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) to enable accurate quantification of drugs and metabolites in biological matrices.
• Mechanistic Investigation: Employed in Deuterium Kinetic Isotope Effect (DKIE) studies to elucidate reaction mechanisms and pathways in chemical and biochemical processes.
• Agrochemical Development: Used in the research and development of novel, isotopically labeled pesticides and herbicides for environmental fate and metabolism studies.
• Analytical Chemistry: Preparation of certified reference materials (CRMs) and high-purity standards for calibration and method validation in regulatory and quality control laboratories.

Basic Information

Product Name	n-Boc-n-Methylpiperazine-D8
CAS No.	1189436-83-6
Molecular Formula	C10H11D8N2O2
Molecular Weight	203.30 g/mol
Synonyms	1-Boc-4-Methylpiperazine-D8; tert-Butyl 4-Methylpiperazine-1-carboxylate-D8; 1-(tert-Butoxycarbonyl)-4-methylpiperazine-D8; N-Boc-N'-Methylpiperazine-D8; N-(tert-Butoxycarbonyl)-N-methylpiperazine-D8; Boc-N-Methylpiperazine-D8; 4-Methyl-1-piperazinecarboxylic acid 1,1-dimethylethyl ester-D8; Deuterated Boc-Methylpiperazine
EINECS	Contact for details

Quality Control

Our n-Boc-n-Methylpiperazine-D8 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and Mass Spectrometry, to confirm isotopic purity, chemical purity, and identity. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.