Description

1-[3,5-Bis(Phenylmethoxy)Phenyl]-2-[[1,1,1,3,3,3-Hexadeuterio-2-(Trideuteriomethyl)Propan-2-Yl]Amino]Ethanol is a deuterated chemical compound of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a stable isotope-labeled analog, which is essential for precise pharmacokinetic, metabolic, and mass spectrometry studies. This high-purity compound is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery and development, particularly for creating internal standards and conducting tracer studies.

Application

• Pharmaceutical Reference Standard: Used as a certified internal standard for the accurate quantification of its non-deuterated counterpart in bioanalytical methods (LC-MS/MS).
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a stable isotope tracer to study the absorption, distribution, metabolism, and excretion (ADME) profiles of lead drug candidates.
• Metabolite Identification: Aids in the definitive identification and structural elucidation of drug metabolites in complex biological matrices.
• Mechanistic Studies: Enables detailed investigation of enzymatic pathways and reaction mechanisms without interference from the natural isotopic background.
• Process Chemistry & Impurity Profiling: Utilized in the development and validation of manufacturing processes to track and quantify potential impurities.
• Clinical Research: Supports clinical trial studies requiring highly sensitive and specific analytical methods for patient sample analysis.

Basic Information

Product Name	1-[3,5-Bis(Phenylmethoxy)Phenyl]-2-[[1,1,1,3,3,3-Hexadeuterio-2-(Trideuteriomethyl)Propan-2-Yl]Amino]Ethanol
CAS No.	1189428-81-6
Molecular Formula	C26H26D9NO3
Molecular Weight	~416.62 g/mol
Synonyms	Deuterated Terbutaline-d9; 1-[3,5-Bis(benzyloxy)phenyl]-2-[(1,1,1,3,3,3-hexadeuterio-2-(trideuteriomethyl)propan-2-yl)amino]ethanol; Terbutaline-d9 (hexadeuterated); (RS)-Terbutaline-d9; α-[(tert-Butyl-d9)amino]methyl]-3,5-bis(benzyloxy)benzyl alcohol; Bricanyl-d9; Brethine-d9
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity for research applications. Each batch is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ²H), High-Resolution Mass Spectrometry (HRMS), and HPLC. A comprehensive Certificate of Analysis (COA) is provided, detailing isotopic purity (D-enrichment), chemical purity, and confirming identity. We support compliance with cGMP and ISO 9001 standards for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (²H NMR/MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.