Description

2-Deuterio-2-(2,3,3,4,4,5,5,6,6-Nonadeuteriopiperidin-2-Yl)-2-Phenylacetamide CAS NO 1189426-25-2 is a high-purity, deuterium-labeled organic compound, specifically designed as a stable isotope-labeled internal standard for advanced analytical applications. This compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry, where it compensates for matrix effects and instrument variability. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical research.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference compound for the precise quantification of its non-deuterated counterpart or related analytes in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential in studies to track the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical candidates, enabling accurate measurement of drug and metabolite concentrations.
• Bioanalytical Method Development and Validation: Used to develop, optimize, and validate robust, regulatory-compliant (e.g., FDA, EMA) analytical methods for preclinical and clinical trials.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Supports accurate drug level monitoring in patient samples to ensure therapeutic efficacy and safety.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in this gold-standard technique for achieving the highest possible accuracy and traceability in quantitative analysis.
• Metabolomics and Proteomics Research: Facilitates the accurate relative and absolute quantification of small molecules and peptides in discovery-phase research.

Basic Information

Product Name	2-Deuterio-2-(2,3,3,4,4,5,5,6,6-Nonadeuteriopiperidin-2-Yl)-2-Phenylacetamide
CAS No.	1189426-25-2
Molecular Formula	C13D10H9N2O
Molecular Weight	~223.3 g/mol (deuterated form)
Synonyms	2-(2,2,3,3,4,4,5,5,6,6-D10-2-Piperidinyl)-2-phenyl-D2-acetamide; Deuterated Phenylpiracetam Metabolite Standard; 2-Phenyl-2-(piperidin-2-yl)acetamide-d12; (2R)-2-Amino-2-phenyl-N-(piperidin-2-yl)acetamide-d12 (labeled); Isotope-labeled internal standard for Phenylpiracetam analysis; d12-2-Phenyl-2-(2-piperidinyl)acetamide
EINECS	Contact for details

Quality Control

Every batch of our deuterated standards is produced and analyzed under strict quality systems to ensure isotopic purity, chemical purity, and structural integrity. We provide comprehensive Certificates of Analysis (COA) detailing results from NMR (1H, 13C), mass spectrometry (for isotopic enrichment), and HPLC for chemical purity. Our quality commitment aligns with the standards expected for GMP/GLP-compliant research. Certificates of Analysis (COA) are available upon request and with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Under these conditions, the product is stable for at least two years from the date of receipt. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.