Description

Desalkyl Ebastine-D5 is a deuterated analog of a key metabolite of the antihistamine ebastine, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and bioequivalence studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control departments for precise mass spectrometry-based assays.

Application

• Internal Standard for LC-MS/MS quantification of ebastine and its metabolites in biological matrices (plasma, serum, urine).
• Reference material for method development and validation in pharmaceutical research and development.
• Critical component in bioanalytical studies for drug metabolism and pharmacokinetics (DMPK).
• Quality control and assurance testing in the manufacturing of active pharmaceutical ingredients (APIs).
• Use in clinical and forensic toxicology for the accurate detection and quantification of antihistamines.
• Supporting analytical work for regulatory submissions to agencies like the FDA and EMA.

Basic Information

Product Name	Desalkyl Ebastine-D5
CAS No.	1189424-36-9
Molecular Formula	C32H36D5NO2
Molecular Weight	474.70 g/mol (approx.)
Synonyms	4-(4-Benzhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl)butan-1-one-d5; Carebastine-d5 (deuterated metabolite); Ebastine Metabolite-d5; Desalkylebastine-d5; Deuterated Desalkyl Ebastine; [2H5]-Desalkyl Ebastine; Ebastine-d5 Metabolite; Internal Standard for Ebastine LC-MS
EINECS	Contact for details

Quality Control

Our Desalkyl Ebastine-D5 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, isotopic purity (D-content), and impurity profile. We adhere to relevant industry standards for reference materials, and our quality protocols are designed to meet the stringent requirements of pharmaceutical analysis and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.