Description

1-(3,4,5-Trifluorophenyl)-1H-Pyrrole-2,5-Dione is a high-value fluorinated maleimide derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the precise introduction of a trifluoromethylphenyl-substituted pyrrole-2,5-dione scaffold, which is essential for modulating the electronic and steric properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients, particularly where enhanced bioavailability and metabolic stability are required. CAS number 1188945-12-1.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in developing new generation herbicides, fungicides, and insecticides that leverage the stability of the fluorinated aromatic system.
• Material Science: Serves as a monomer or cross-linking agent in the creation of specialized polymers with unique thermal and chemical resistance properties.
• Organic Electronic Materials: Investigated as a component for electron-transport materials or as a building block in organic semiconductors due to its electron-deficient structure.
• Chemical Biology Probes: Utilized in the design of activity-based probes and covalent inhibitors for studying enzyme function and protein labeling.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical manufacturers for bespoke synthesis projects requiring this specific fluorinated motif.

Basic Information

Product Name	1-(3,4,5-Trifluorophenyl)-1H-Pyrrole-2,5-Dione
CAS No.	1188945-12-1
Molecular Formula	C10H4F3NO2
Molecular Weight	227.14 g/mol
Synonyms	1-(3,4,5-Trifluorophenyl)-1H-pyrrole-2,5-dione; 3,4,5-Trifluorophenylmaleimide; N-(3,4,5-Trifluorophenyl)maleimide; 2,5-Pyrrolidinedione, 1-(3,4,5-trifluorophenyl)-; 1-(3,4,5-Trifluorophenyl)maleimide; 1H-Pyrrole-2,5-dione, 1-(3,4,5-trifluorophenyl)-; 1188945-12-1; 3,4,5-Trifluoro-N-phenylmaleimide
EINECS	Contact for details

Quality Control

Our 1-(3,4,5-Trifluorophenyl)-1H-Pyrrole-2,5-Dione is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.