Description

Nifuroxazide-D4 CAS NO 1188487-83-3 is a deuterated isotopologue of the nitrofuran antibiotic nifuroxazide, where four hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring the highest accuracy and reliability in analytical measurements. It is a critical material for pharmaceutical research and development, clinical laboratories, and contract research organizations (CROs) engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the analysis of nifuroxazide in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in studies to track the absorption, distribution, metabolism, and excretion (ADME) of the parent drug.
• Bioanalytical Method Development and Validation: Critical for developing and validating robust, regulatory-compliant assays for therapeutic drug monitoring or clinical trials.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of potential deuterated impurities or metabolites in active pharmaceutical ingredient (API) batches.
• Clinical Research: Supports accurate measurement of drug concentrations in patient plasma, serum, or urine samples during clinical studies.
• Forensic and Anti-Doping Analysis: Provides a reliable reference for confirmatory testing in specialized analytical fields requiring high precision.

Basic Information

Product Name	Nifuroxazide-D4
CAS No.	1188487-83-3
Molecular Formula	C12H5D4N3O5
Molecular Weight	279.24 g/mol
Synonyms	4-Hydroxy-N'-[(5-nitro-2-furanyl)methylene]benzohydrazide-d4; 5-Nitro-2-furaldehyde 4-hydroxybenzoylhydrazone-d4; Nifuroxazide (tetradeuterated); Nifuroxazide-d4; [2H4]-Nifuroxazide; 5-Nitro-2-furaldehyde (4-hydroxybenzoyl)hydrazone-d4; Antinal-d4; Ercefuryl-d4
EINECS	Contact for details

Quality Control

Our Nifuroxazide-D4 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (by MS), and residual solvent content. We support compliance with ICH Q2(R1), FDA, and EMA guidelines for bioanalytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98.0 atom % D
Chemical Purity (HPLC)	≥95.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.