Description

4-Bromo-2,6-Difluorobenzenethiol is a high-purity organosulfur building block characterized by its reactive thiol (-SH) group and halogenated aromatic ring. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing sulfur-containing heterocycles and functionalized aromatics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing benzothiophene or related sulfur heterocycles.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the difluorobenzene moiety imparts specific biological activity and metabolic stability.
• Ligand Precursor: Serves as a starting material for the preparation of specialized ligands in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the creation of novel polymers, liquid crystals, and organic electronic materials due to its ability to introduce sulfur and halogen functionalities.
• Cross-Coupling Reactions: The bromine atom makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create more complex biaryl structures.
• Chemical Derivatization: The thiol group allows for further functionalization through alkylation, oxidation to disulfides, or conjugation with other molecules.

Basic Information

Product Name	4-Bromo-2,6-Difluorobenzenethiol
CAS No.	1188368-59-3
Molecular Formula	C6H3BrF2S
Molecular Weight	225.06 g/mol
Synonyms	2,6-Difluoro-4-bromobenzenethiol; 4-Bromo-2,6-difluorothiophenol; 4-Bromo-2,6-difluorophenyl mercaptan; Benzenethiol, 4-bromo-2,6-difluoro-; 1188368-59-3; 4-Br-2,6-F2-C6H2SH
EINECS	Contact for details

Quality Control

Our 4-Bromo-2,6-Difluorobenzenethiol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This product is easily oxidized and light-sensitive. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.